200541

• Gene Symbol: Bcl2
• Gene Name: B-cell CLL/lymphoma 2
• Gene Aliases: Bcl-2
• Chromosome Location: Chr.13: 26605426 - 26769374 on Build Rnor_6.0
• UniGene ID: Rn.9996
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Bcl2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_016993.1	NP_058689.1	2	987
GenBank mRNA	L14680.1	-	2	987

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_000633, M14745, BC027258, X06487, M13994.
This siRNA also targets the following transcripts in Mouse: NM_009741, AK049473, BC095964.

Gene Ontology Categories:

Process(es)

protein polyubiquitination
cell morphogenesis
ossification
ovarian follicle development
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
behavioral fear response
response to hypoxia
leukocyte homeostasis
B cell homeostasis
kidney development
release of cytochrome c from mitochondria
regulation of cell-matrix adhesion
lymphocyte homeostasis
lymphoid progenitor cell differentiation
B cell lineage commitment
T cell lineage commitment
immune system development
response to ischemia
renal system process
protein dephosphorylation
melanin metabolic process
regulation of nitrogen utilization
cellular calcium ion homeostasis
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
actin filament organization
axonogenesis
brain development
aging
cell aging
response to nutrient
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
apoptotic mitochondrial changes
response to heat
response to toxic substance
post-embryonic development
organ morphogenesis
response to organic substance
response to inorganic substance
response to iron ion
response to aluminum ion
response to UV-B
response to gamma radiation
regulation of gene expression
negative regulation of calcium ion transport into cytosol
regulation of glycoprotein biosynthetic process
mesenchymal cell development
positive regulation of neuron maturation
response to organic cyclic compound
positive regulation of smooth muscle cell migration
cell growth
single organismal cell-cell adhesion
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cochlear nucleus development
gland morphogenesis
regulation of transmembrane transporter activity
hemopoiesis
B cell differentiation
T cell differentiation
negative regulation of ossification
positive regulation of cell growth
negative regulation of cell growth
melanocyte differentiation
negative regulation of cell migration
positive regulation of B cell proliferation
response to caffeine
hair follicle morphogenesis
axon regeneration
regulation of protein stability
endoplasmic reticulum calcium ion homeostasis
glomerulus development
negative regulation of cellular pH reduction
response to insulin
regulation of protein localization
negative regulation of myeloid cell apoptotic process
T cell differentiation in thymus
positive regulation of peptidyl-serine phosphorylation
response to L-ascorbic acid
negative regulation of osteoblast proliferation
response to cytokine
glial cell apoptotic process
response to nicotine
organ growth
growth
positive regulation of multicellular organism growth
B cell proliferation
cellular response to glucose starvation
response to drug
response to hydrogen peroxide
regulation of apoptotic process
T cell homeostasis
negative regulation of apoptotic process
regulation of programmed cell death
positive regulation of catalytic activity
CD8-positive, alpha-beta T cell lineage commitment
response to peptide hormone
pigmentation
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
negative regulation of neuron apoptotic process
ear development
response to estrogen
regulation of viral genome replication
response to ethanol
positive regulation of melanocyte differentiation
negative regulation of mitotic cell cycle
negative regulation of retinal cell programmed cell death
response to copper ion
regulation of mitochondrial membrane permeability
focal adhesion assembly
developmental pigmentation
regulation of developmental pigmentation
positive regulation of developmental pigmentation
spleen development
thymus development
response to steroid hormone
digestive tract morphogenesis
developmental growth
oocyte development
oligodendrocyte differentiation
positive regulation of skeletal muscle fiber development
pigment granule organization
homeostasis of number of cells within a tissue
regulation of catalytic activity
B cell receptor signaling pathway
response to glucocorticoid
neuron apoptotic process
response to corticosterone
response to cAMP
response to folic acid
response to electrical stimulus
defense response to virus
regulation of cell cycle
regulation of mitochondrial membrane potential
regulation of calcium ion transport
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to organic substance
cellular response to hypoxia
reactive oxygen species metabolic process
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of anoikis
negative regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

protease binding
protein binding
transcription factor binding
channel activity
channel inhibitor activity
protein phosphatase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
BH domain binding
BH3 domain binding
protein phosphatase 2A binding