20476

• Gene Symbol: NRG1
• Gene Name: neuregulin 1
• Gene Aliases: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
• Chromosome Location: Chr.8: 31639222 - 32771716 on Build GRCh38
• UniGene ID: Hs.453951
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NRG1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001159995.2	NP_001153467.1	5	622
	NM_001159996.2	NP_001153468.1	2	351
	NM_001159999.2	NP_001153471.1	6	673
	NM_001160001.2	NP_001153473.1	4	571
	NM_001160002.1	NP_001153474.1	5	1029
	NM_001160004.2	NP_001153476.1	6	1080
	NM_001160005.1	NP_001153477.1	4	978
	NM_001160007.1	NP_001153479.1	4	978
	NM_001160008.1	NP_001153480.1	6	1080
	NM_001322197.1	NP_001309126.1	2	351
	NM_001322201.1	NP_001309130.1	5	622
	NM_001322202.1	NP_001309131.1	4	571
	NM_001322205.1	NP_001309134.1	2	1714
	NM_001322206.1	NP_001309135.1	2	1714
	NM_001322207.1	NP_001309136.1	2	1714
	NM_004495.3	NP_004486.2	6	1080
	NM_013956.4	NP_039250.2	6	1080
	NM_013957.4	NP_039251.2	6	1080
	NM_013958.3	NP_039252.2	6	1080
	NM_013959.3	NP_039253.1	2	1714
	NM_013960.4	NP_039254.1	6	1080
	NM_013962.2	NP_039256.2	4	1339
	NM_013964.4	NP_039258.1	6	1080
	XM_005273486.3	XP_005273543.1	2	1714
	XM_005273487.3	XP_005273544.1	2	1714
	XM_011544512.2	XP_011542814.1	6	863
	XM_017013365.1	XP_016868854.1	6	792
	XM_017013366.1	XP_016868855.1	6	792
	XM_017013367.1	XP_016868856.1	4	573
	XM_017013368.1	XP_016868857.1	4	910
	XM_017013369.1	XP_016868858.1	2	1682
	XM_017013370.1	XP_016868859.1	2	1677
	XM_017013371.1	XP_016868860.1	6	792
	XM_017013372.1	XP_016868861.1	6	792
GenBank mRNA	AB451331.1	-	6	563
	AB451475.1	-	6	563
	AF026146.1	-	6	1010
	AK097005.1	-	7	927
	AK223435.1	-	2	1221
	AK289927.1	-	2	1714
	AK290730.1	-	6	979
	AK293240.1	-	2	186
	AK293270.1	-	2	259
	AK298132.1	-	6	1080
	BC006492.2	-	6	1052
	BC007675.2	-	2	1371
	BC064587.1	-	2	1167
	BC073871.1	-	2	1335
	BC144446.1	-	6	628
	BC150609.1	-	6	628	9056979
	BT007389.1	-	2	728
	CN603652.1	-	6	591
	CN603654.1	-	4	489
	CN603661.1	-	2	351
	CR450288.1	-	2	728
	DC425692.1	-	2	271
	EF372273.1	-	4	407
	EF372274.1	-	4	407
	EF372275.1	-	5	458
	EF372276.1	-	5	458
	EF372277.1	-	4	407
	EF517296.1	-	6	509
	EF517297.1	-	5	458
	EU359055.1	-	4	458
	EU363508.1	-	5	509
	EU363509.1	-	4	458
	EU363510.1	-	6	560
	GQ983557.1	-	4	571
	GQ983558.1	-	4	398
	L12260.1	-	4	1367
	L12261.1	-	6	956
	L41827.1	-	2	1228
	M94165.1	-	6	695
	M94166.1	-	6	655
	M94167.1	-	6	1023
	M94168.1	-	6	1055
	S68256.1	-	6	635
	U02326.1	-	6	671
	U02327.1	-	4	199
	U02328.1	-	4	286
	U02329.1	-	4	210
	U02330.1	-	5	365

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001271122, NM_001271121, NM_031588, NM_001271119, NM_001271124, and others.
This siRNA also targets the following transcripts in Mouse: NM_178591, AY227027, AK141037, BC151113, AY648975, and others.

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
cell morphogenesis
startle response
cardiac conduction system development
ventricular trabecula myocardium morphogenesis
cell communication
activation of transmembrane receptor protein tyrosine kinase activity
nervous system development
synapse assembly
peripheral nervous system development
locomotory behavior
regulation of blood pressure
positive regulation of cell proliferation
embryo development
neural crest cell development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
glucose transport
peptidyl-tyrosine phosphorylation
glial cell fate commitment
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
positive regulation of myelination
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
wound healing
negative regulation of protein catabolic process
myelination
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
positive regulation of GTPase activity
neurotransmitter receptor metabolic process
positive regulation of axon extension
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of Ras protein signal transduction
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
neuron fate commitment
oligodendrocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of secretion
positive regulation of striated muscle cell differentiation
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
positive regulation of dendritic spine development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of protein targeting to mitochondrion
positive regulation of protein localization to cell surface
regulation of cell motility
positive regulation of cardiac muscle cell differentiation
negative regulation of neuron migration

Function(s)

transcription cofactor activity
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
cytokine activity
ErbB-2 class receptor binding
integrin binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity