214168

Gene Symbol:

HLA-DRB1 HLA-DQB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DRB6 LOC105369230

Gene Name:

major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DQ beta 1

major histocompatibility complex, class II, DR beta 3

major histocompatibility complex, class II, DR beta 4

major histocompatibility complex, class II, DR beta 5

major histocompatibility complex, class II, DR beta 6 (pseudogene)

HLA class II histocompatibility antigen, DRB1-7 beta chain

Gene Aliases:

DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1

CELIAC1, HLA-DQB, HLA-DRB1, IDDM1

DRB1, DRw10, HLA-DR1B, HLA-DR3B, HLA-DRB, SS1

DR-4, DR4, DRB4, HLA-DR4B

HLA-DRB

-

HLA-DRB1

Chromosome Location:

Chr.6: 32578769 - 32589836 on Build GRCh38

Chromosome Location:

Chr.6: 32659464 - 32666689 on Build GRCh38

Chromosome Location:

-

Chromosome Location:

-

Chromosome Location:

Chr.6: 32517343 - 32530316 on Build GRCh38

Chromosome Location:

Chr.6: 32552713 - 32560002 on Build GRCh38

Chromosome Location:

-

UniGene ID:

Hs.534322

Hs.409934

Hs.696211

Hs.534322

Hs.485130

Hs.723344

Hs.696211

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

-

-

-

-

siRNA Details

Gene Symbol: HLA-DRB1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001243965.1	NP_001230894.1	4	777
	NM_002124.3	NP_002115.2	4	777
GenBank mRNA	AF291675.1	-	4	683
	AJ297583.1	-	4	683
	AJ297585.1	-	4	683
	AJ297586.2	-	4	683
	AJ297587.1	-	4	683
	AJ697892.1	-	4	692
	AJ697893.1	-	4	692
	AK289463.1	-	4	746
	AK291987.1	-	4	777
	AY626551.1	-	4	683
	AY770514.1	-	4	683
	AY935719.1	-	4	683
	AY961062.1	-	4	683
	AY961063.1	-	4	683
	AY961065.1	-	4	683
	AY961066.1	-	4	683
	AY961068.1	-	4	683
	AY961072.1	-	4	683
	AY961073.1	-	4	683
	AY961076.1	-	4	683
	AY961077.1	-	4	683
	AY961078.1	-	4	683
	BC007920.2	-	4	729	4309837
	BC008403.1	-	4	746	4272571
	BC024269.1	-	4	726	4852401
	BC031023.1	-	4	746	4695321
	BC033827.1	-	4	726	5216243
	BC108922.1	-	4	738	40023604
	DQ002917.1	-	4	683
	DQ090958.1	-	4	683
	DQ140279.1	-	4	743
	HG974574.1	-	4	683
	HG974596.1	-	4	683
	HG974600.1	-	4	683
	HM067861.1	-	4	683
	HM067862.1	-	4	683
	HM067863.1	-	4	683
	KJ534866.1	-	4	683
	L02545.1	-	4	697
	L42143.1	-	4	683
	L76133.1	-	4	723
	M11161.1	-	4	683
	M11867.1	-	4	712
	M14661.1	-	3	545
	M14662.1	-	3	596
	M16957.1	-	3	596
	M16959.1	-	3	596
	M17378.1	-	3	596
	M17381.1	-	3	596
	M17384.1	-	3	596
	M20138.1	-	4	685
	M20430.1	-	4	726
	M20504.1	-	5	718
	M21008.1	-	3	576
	M26038.1	-	4	729
	M27635.1	-	4	720
	M28583.1	-	5	722
	M28584.1	-	4	654
	M33600.1	-	4	753
	U56640.1	-	3	540
	U65585.1	-	4	723
	U95817.1	-	3	596
	X00699.1	-	4	718
	X00700.1	-	4	687
X02902.1	-	4	739
X03069.1	-	4	745

Gene Symbol: HLA-DQB1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	M20505.1	-	4	660

Gene Symbol: HLA-DRB3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_022555.3	NP_072049.2	4	723
GenBank mRNA	A06800.1	-	4	719
	AF000448.1	-	4	596
	AF192258.1	-	3	596
	AF192259.1	-	3	596
	AF199236.2	-	5	704
	AK226043.1	-	4	749
	AY138123.1	-	4	683
	BC001023.2	-	4	743	3345335
	BC008987.1	-	4	707	4184806
	BC106057.1	-	4	786	4385464
	M17380.1	-	3	596
	M28991.1	-	4	641
	M28992.1	-	4	602
	U66825.1	-	4	723
	U95819.1	-	4	697
	V00522.1	-	4	718

Gene Symbol: HLA-DRB4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_021983.4	NP_068818.4	4	754
GenBank mRNA	AF048707.1	-	3	544
	AF361548.1	-	5	692
	AF361549.1	-	5	692
	AK225683.1	-	4	746
	AK225690.1	-	4	746
	AK291499.1	-	4	746
	AK292151.1	-	5	734
	AK293020.1	-	4	787
	AY961064.1	-	4	683
	AY961067.1	-	4	683
	AY961070.2	-	4	683
	BC005312.1	-	5	746	3933019
	DQ284431.1	-	4	744
	DQ284433.1	-	4	745
	GQ891550.1	-	4	683
	M15178.1	-	5	625
	M17385.1	-	3	596

Gene Symbol: HLA-DRB5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002125.3	NP_002116.2	4	688
	XM_011514562.2	XP_011512864.1	4	775
GenBank mRNA	AB062112.2	-	4	727
	AF490771.1	-	4	664
	AJ297582.1	-	4	683
	AK292140.1	-	4	746
	AK314834.1	-	4	730
	BC009234.2	-	4	726	4054398
	M15992.1	-	3	596
	M16086.1	-	3	466
	M16954.1	-	3	596
	M16956.1	-	3	596
	M17377.1	-	3	596
	M17379.1	-	3	596
	M17382.1	-	3	596
	M17383.1	-	3	596
	M20429.1	-	4	688
	M20503.1	-	4	746
	M27689.1	-	3	596
	M32578.1	-	4	744
	M57648.1	-	4	741
	U66826.1	-	4	723
	X99895.1	-	4	690

Gene Symbol: HLA-DRB6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NR_001298.1		4	771
GenBank mRNA	AF005487.1	-	4	771
	L76565.1	-	4	842

Gene Symbol: LOC105369230
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	HG974601.1	-	4	683
	HM067848.1	-	4	683

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

polysaccharide assembly with MHC class II protein complex
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
T cell receptor signaling pathway
interferon-gamma-mediated signaling pathway
signal transduction

Function(s)

MHC class II protein complex binding
peptide antigen binding
MHC class II receptor activity