214529

• Gene Symbol: BCL2
• Gene Name: BCL2, apoptosis regulator
• Gene Aliases: Bcl-2, PPP1R50
• Chromosome Location: Chr.18: 63123346 - 63319778 on Build GRCh38
• UniGene ID: Hs.150749
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: BCL2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000633.2	NP_000624.2	2	1031
	NM_000657.2	NP_000648.2	2	1031
	XM_011526135.2	XP_011524437.1	1	1650
	XM_017025917.1	XP_016881406.1	2	1429
GenBank mRNA	BC027258.1	-	2	927	4511027
	EU287875.1	-	1	538
	M13994.1	-	1	1996
	M13995.1	-	1	684
	M14745.1	-	1	569
	X06487.1	-	2	1424

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_016993, U34964, AF512835, L14680, AF149299.
This siRNA also targets the following transcripts in Mouse: NM_009741, NM_177410, BC068988, AK049473, BC095964, and others.

Gene Ontology Categories:

Process(es)

protein polyubiquitination
ossification
ovarian follicle development
metanephros development
branching involved in ureteric bud morphogenesis
behavioral fear response
B cell homeostasis
release of cytochrome c from mitochondria
regulation of cell-matrix adhesion
lymphoid progenitor cell differentiation
B cell lineage commitment
response to ischemia
renal system process
protein dephosphorylation
melanin metabolic process
regulation of nitrogen utilization
apoptotic process
humoral immune response
cellular response to DNA damage stimulus
actin filament organization
axonogenesis
female pregnancy
cell aging
male gonad development
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to radiation
response to toxic substance
post-embryonic development
response to iron ion
response to UV-B
response to gamma radiation
regulation of gene expression
negative regulation of autophagy
negative regulation of calcium ion transport into cytosol
regulation of glycoprotein biosynthetic process
mesenchymal cell development
positive regulation of neuron maturation
positive regulation of smooth muscle cell migration
cell growth
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cochlear nucleus development
gland morphogenesis
regulation of transmembrane transporter activity
negative regulation of ossification
positive regulation of cell growth
negative regulation of cell growth
melanocyte differentiation
negative regulation of cell migration
positive regulation of B cell proliferation
hair follicle morphogenesis
axon regeneration
regulation of protein stability
endoplasmic reticulum calcium ion homeostasis
glomerulus development
negative regulation of cellular pH reduction
negative regulation of myeloid cell apoptotic process
T cell differentiation in thymus
positive regulation of peptidyl-serine phosphorylation
negative regulation of osteoblast proliferation
response to cytokine
response to nicotine
organ growth
positive regulation of multicellular organism growth
B cell proliferation
cellular response to glucose starvation
response to drug
response to hydrogen peroxide
T cell homeostasis
negative regulation of apoptotic process
positive regulation of catalytic activity
CD8-positive, alpha-beta T cell lineage commitment
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
negative regulation of neuron apoptotic process
ear development
regulation of viral genome replication
positive regulation of melanocyte differentiation
negative regulation of retinal cell programmed cell death
regulation of mitochondrial membrane permeability
focal adhesion assembly
spleen development
thymus development
digestive tract morphogenesis
oocyte development
positive regulation of skeletal muscle fiber development
pigment granule organization
homeostasis of number of cells within a tissue
B cell receptor signaling pathway
response to glucocorticoid
neuron apoptotic process
defense response to virus
regulation of mitochondrial membrane potential
negative regulation of mitochondrial depolarization
regulation of calcium ion transport
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to organic substance
cellular response to hypoxia
reactive oxygen species metabolic process
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of reactive oxygen species metabolic process
negative regulation of anoikis
negative regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

protease binding
protein binding
transcription factor binding
channel activity
channel inhibitor activity
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
BH3 domain binding
protein phosphatase 2A binding