223873

• Gene Symbol: Sirt2
• Gene Name: sirtuin 2
• Gene Aliases: -
• Chromosome Location: Chr.1: 86948881 - 86971954 on Build Rnor_6.0
• UniGene ID: Rn.59887
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Sirt2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001008368.1	NP_001008369.1	8	956
	XM_006228672.2	XP_006228734.1	8	688
	XM_006228673.2	XP_006228735.1	9	693
	XM_006228675.1	XP_006228737.1	8	688
	XM_006228676.2	XP_006228738.1	9	693
GenBank mRNA	BC086545.1	-	8	956	7134377
	FQ212805.1	-	8	615
	FQ216424.1	-	4	284

More Information

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein deacetylation
autophagy
mitotic nuclear division
central nervous system development
negative regulation of cell proliferation
negative regulation of autophagy
negative regulation of peptidyl-threonine phosphorylation
phosphatidylinositol 3-kinase signaling
histone deacetylation
substantia nigra development
myelination in peripheral nervous system
regulation of myelination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
peptidyl-lysine deacetylation
cellular response to hepatocyte growth factor stimulus
negative regulation of protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
protein kinase B signaling
cellular lipid catabolic process
regulation of fat cell differentiation
negative regulation of fat cell differentiation
positive regulation of meiotic nuclear division
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
negative regulation of oligodendrocyte differentiation
cell division
meiotic cell cycle
regulation of cell cycle
positive regulation of cell division
positive regulation of attachment of spindle microtubules to kinetochore
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
cellular response to caloric restriction
negative regulation of oligodendrocyte progenitor proliferation
histone H3 deacetylation
histone H4 deacetylation
cellular response to molecule of bacterial origin
cellular response to hypoxia
cellular response to epinephrine stimulus
tubulin deacetylation
positive regulation of execution phase of apoptosis
positive regulation of oocyte maturation
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of defense response to bacterium
ripoptosome assembly involved in necroptotic process
negative regulation of reactive oxygen species metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Function(s)

molecular_function
chromatin binding
histone deacetylase activity
transcription factor binding
zinc ion binding
NAD-dependent histone deacetylase activity
protein deacetylase activity
NAD-dependent protein deacetylase activity
histone acetyltransferase binding
histone deacetylase binding
tubulin deacetylase activity
ubiquitin binding
NAD-dependent histone deacetylase activity (H4-K16 specific)
beta-tubulin binding
NAD+ binding