224830

• Gene Symbol: OPTN
• Gene Name: optineurin
• Gene Aliases: ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
• Chromosome Location: Chr.10: 13100082 - 13138276 on Build GRCh38
• UniGene ID: Hs.332706
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: OPTN
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001008211.1	NP_001008212.1	10, 11	1447
	NM_001008212.1	NP_001008213.1	9, 10	1378
	NM_001008213.1	NP_001008214.1	10, 11	1432
	NM_021980.4	NP_068815.2	8, 9	1226
GenBank mRNA	AF061034.1	-	10, 11	1320
	AF420371.1	-	10, 11	1304
	AF420372.1	-	8, 9	1083
	AF420373.1	-	9, 10	1235
	AK055403.1	-	9, 10	1667
	AK122746.1	-	1, 2	741
	AK303715.1	-	8, 9	1244
	AK316171.1	-	8, 9	1266
	BC013876.2	-	8, 9	1139	3831267
	BC032762.1	-	10, 11	1334	3457195
	KU178502.1	-	7, 8	994

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_145081, XM_006254263, XM_006254262, XM_006254264, XM_008771853, and others.
This siRNA also targets the following transcripts in Mouse: NM_181848, AK186654, AY071834, BC061185, BC024755, and others.

Gene Ontology Categories:

Process(es)

protein targeting to Golgi
G2/M transition of mitotic cell cycle
negative regulation of receptor recycling
Golgi organization
signal transduction
cell death
macroautophagy
Golgi to plasma membrane protein transport
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
defense response to Gram-negative bacterium
parkin-mediated mitophagy in response to mitochondrial depolarization
Golgi ribbon formation
xenophagy

Function(s)

protein binding
protein C-terminus binding
Rab GTPase binding
protein binding, bridging
polyubiquitin binding
identical protein binding
K63-linked polyubiquitin binding