244983

Gene Symbol:

HMGB1 ACYP2 CTCFL

Gene Name:

high mobility group box 1

acylphosphatase 2

CCCTC-binding factor like

Gene Aliases:

HMG-1, HMG1, HMG3, SBP-1

ACYM, ACYP

BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2

Chromosome Location:

Chr.13: 30457916 - 30617597 on Build GRCh38

Chromosome Location:

Chr.2: 53970838 - 54305300 on Build GRCh38

Chromosome Location:

Chr.20: 57495965 - 57525652 on Build GRCh38

UniGene ID:

Hs.434102

Hs.516173

Hs.131543

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

siRNA Details

Gene Symbol: HMGB1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001313892.1	NP_001300821.1	2	220
	NM_001313893.1	NP_001300822.1	2	980
	NM_002128.5	NP_002119.1	2	223
GenBank mRNA	AA430980.1	-	2	223
	AB208998.1	-	2	107
	AK057120.1	-	2	157
	AK122825.1	-	2	982
	AK291494.1	-	2	194
	AK304506.1	-	2	194
	AK310975.1	-	2	169
	AV763680.1	-	2	220
	AX795278.1	-	2	115
	AY377859.1	-	1	39
	BC003378.1	-	2	115	2901382
	BC030981.1	-	2	134	4041682
	BC066889.1	-	2	118	5268698
	BC067732.1	-	2	138	4818524
	BC141844.1	-	2	116	8860319
	BT006940.1	-	1	39
	BT020159.1	-	1	39
	BX647267.1	-	1	603
	CB051582.1	-	2	231
	CR456863.1	-	1	39
	CR749614.1	-	2	211
	X12597.1	-	2	91

Gene Symbol: ACYP2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_017005408.1	XP_016860897.1	2	383

Gene Symbol: CTCFL
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	BC137482.1	-	1	74	9021482
	BC137483.1	-	1	74	9021483
	DQ778130.1	-	4	579
	DQ778131.1	-	3	439

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
eye development
myeloid dendritic cell activation
endothelial cell proliferation
activation of innate immune response
plasmacytoid dendritic cell activation
macrophage activation involved in immune response
dendritic cell chemotaxis
inflammatory response to antigenic stimulus
regulation of tolerance induction
regulation of T cell mediated immune response to tumor cell
DNA topological change
base-excision repair
apoptotic DNA fragmentation
DNA recombination
regulation of transcription from RNA polymerase II promoter
autophagy
inflammatory response
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
lung development
neuron projection development
chromatin assembly
regulation of restriction endodeoxyribonuclease activity
activation of protein kinase activity
DNA geometric change
positive regulation of mismatch repair
negative regulation of interferon-gamma production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of tumor necrosis factor production
V(D)J recombination
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
T-helper 1 cell activation
endothelial cell chemotaxis
positive regulation of activated T cell proliferation
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of DNA binding
positive regulation of MAPK cascade
negative regulation of blood vessel endothelial cell migration
T-helper 1 cell differentiation
innate immune response
positive regulation of myeloid cell differentiation
positive regulation of glycogen catabolic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of interleukin-1 secretion
positive regulation of interleukin-1 beta secretion
positive chemotaxis
DNA ligation involved in DNA repair
positive regulation of DNA ligation
response to glucocorticoid
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
positive regulation of wound healing
neutrophil clearance
positive regulation of NIK/NF-kappaB signaling
positive regulation of sprouting angiogenesis
tumor necrosis factor secretion
negative regulation of apoptotic cell clearance
positive regulation of interleukin-6 secretion
regulation of nucleotide-excision repair
positive regulation of dendritic cell differentiation
phosphate-containing compound metabolic process

Function(s)

four-way junction DNA binding
bubble DNA binding
lipopolysaccharide binding
phosphatidylserine binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
double-stranded RNA binding
single-stranded RNA binding
cytokine activity
protein binding
transcription factor binding
DNA binding, bending
calcium-dependent protein kinase regulator activity
lyase activity
C-X-C chemokine binding
protein kinase activator activity
chemoattractant activity
poly(A) RNA binding
RAGE receptor binding
DNA polymerase binding
repressing transcription factor binding
supercoiled DNA binding
acylphosphatase activity