244984

Gene Symbol:

HMGB1 CTCFL HMGB1P34

Gene Name:

high mobility group box 1

CCCTC-binding factor like

high mobility group box 1 pseudogene 34

Gene Aliases:

HMG-1, HMG1, HMG3, SBP-1

BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2

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Chromosome Location:

Chr.13: 30457916 - 30617597 on Build GRCh38

Chromosome Location:

Chr.20: 57495965 - 57525652 on Build GRCh38

Chromosome Location:

Chr.14: 67615484 - 67616094 on Build GRCh38

UniGene ID:

Hs.434102

Hs.131543

Hs.640300

Species:

Human

Species Specific ID (Flybase ID):

-

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siRNA Details

Gene Symbol: HMGB1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001313892.1	NP_001300821.1	2	299
	NM_001313893.1	NP_001300822.1	2	1059
	NM_002128.5	NP_002119.1	2	302
GenBank mRNA	AA430980.1	-	2	303
	AB208998.1	-	2	186
	AK057120.1	-	2	236
	AK122825.1	-	2	1061
	AK291494.1	-	2	273
	AK304506.1	-	2	273
	AK310975.1	-	2	248
	AV763680.1	-	2	299
	AX795278.1	-	2	194
	AY377859.1	-	1	118
	BC003378.1	-	2	194	2901382
	BC030981.1	-	2	213	4041682
	BC066889.1	-	2	197	5268698
	BC067732.1	-	2	217	4818524
	BC141844.1	-	2	195	8860319
	BT006940.1	-	1	118
	BT020159.1	-	1	118
	BX647267.1	-	1	682
	CB051582.1	-	2	310
	CR456863.1	-	1	118
	CR749614.1	-	2	290
	D63874.1	-	2	194
	X12597.1	-	2	170

Gene Symbol: CTCFL
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	BC137482.1	-	1	153	9021482
	BC137483.1	-	1	153	9021483
	DQ778130.1	-	4	658
	DQ778131.1	-	3	518

Gene Symbol: HMGB1P34
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	BC068102.1	-	1	677

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
eye development
myeloid dendritic cell activation
endothelial cell proliferation
activation of innate immune response
plasmacytoid dendritic cell activation
macrophage activation involved in immune response
dendritic cell chemotaxis
inflammatory response to antigenic stimulus
regulation of tolerance induction
regulation of T cell mediated immune response to tumor cell
DNA topological change
base-excision repair
apoptotic DNA fragmentation
DNA recombination
regulation of transcription from RNA polymerase II promoter
autophagy
inflammatory response
positive regulation of cytosolic calcium ion concentration
regulation of autophagy
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
lung development
neuron projection development
chromatin assembly
regulation of restriction endodeoxyribonuclease activity
activation of protein kinase activity
DNA geometric change
positive regulation of mismatch repair
negative regulation of interferon-gamma production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of tumor necrosis factor production
V(D)J recombination
positive regulation of toll-like receptor 2 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
T-helper 1 cell activation
endothelial cell chemotaxis
positive regulation of activated T cell proliferation
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of DNA binding
positive regulation of MAPK cascade
negative regulation of blood vessel endothelial cell migration
T-helper 1 cell differentiation
innate immune response
positive regulation of myeloid cell differentiation
positive regulation of glycogen catabolic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of interleukin-1 secretion
positive regulation of interleukin-1 beta secretion
positive chemotaxis
DNA ligation involved in DNA repair
positive regulation of DNA ligation
response to glucocorticoid
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
positive regulation of wound healing
neutrophil clearance
positive regulation of NIK/NF-kappaB signaling
positive regulation of sprouting angiogenesis
tumor necrosis factor secretion
negative regulation of apoptotic cell clearance
positive regulation of interleukin-6 secretion
regulation of nucleotide-excision repair
positive regulation of dendritic cell differentiation

Function(s)

four-way junction DNA binding
bubble DNA binding
lipopolysaccharide binding
phosphatidylserine binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
double-stranded RNA binding
single-stranded RNA binding
cytokine activity
protein binding
transcription factor binding
DNA binding, bending
calcium-dependent protein kinase regulator activity
lyase activity
C-X-C chemokine binding
protein kinase activator activity
chemoattractant activity
poly(A) RNA binding
RAGE receptor binding
DNA polymerase binding
repressing transcription factor binding
supercoiled DNA binding