247002

Gene Symbol:

PDPK1 GBA GUK1 LOC100132272 MTDH ZNF785

Gene Name:

3-phosphoinositide dependent protein kinase 1

glucosylceramidase beta

guanylate kinase 1

uncharacterized LOC100132272

metadherin

zinc finger protein 785

Gene Aliases:

PDK1, PDPK2, PDPK2P, PRO0461

GBA1, GCB, GLUC

GMK

-

3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3

-

Chromosome Location:

Chr.16: 2537964 - 2603190 on Build GRCh38

Chromosome Location:

Chr.1: 155234448 - 155244862 on Build GRCh38

Chromosome Location:

Chr.1: 228139643 - 228148955 on Build GRCh38

Chromosome Location:

-

Chromosome Location:

Chr.8: 97643972 - 97730260 on Build GRCh38

Chromosome Location:

Chr.16: 30573219 - 30586038 on Build GRCh38

UniGene ID:

Hs.459691

Hs.282997

Hs.376933

Hs.711405

Hs.377155

Hs.513509

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

-

-

-

siRNA Details

Gene Symbol: PDPK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_011522521.2	XP_011520823.1	1	2862
	XM_011522523.2	XP_011520825.1	1	2867
	XM_017023271.1	XP_016878760.1	1	2867
	XM_017023275.1	XP_016878764.1	1	2873

Gene Symbol: GBA
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AL547558.3	-	2	168
	AU122729.1	-	2	156
	BX382279.2	-	2	156
	BX477204.1	-	2	194

Gene Symbol: GUK1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_005273106.2	XP_005273163.1	1	52

Gene Symbol: LOC100132272
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AK124207.1	-	1	1536

Gene Symbol: MTDH
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_178812.3	NP_848927.2	12	7117
GenBank mRNA	AK123083.1	-	1	1612

Gene Symbol: ZNF785
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_152458.6	NP_689671.2	3	2971

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

stimulatory C-type lectin receptor signaling pathway
type B pancreatic cell development
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
hyperosmotic response
epidermal growth factor receptor signaling pathway
positive regulation of phospholipase activity
regulation of endothelial cell migration
negative regulation of cardiac muscle cell apoptotic process
cell migration
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
calcium-mediated signaling
actin cytoskeleton organization
platelet activation
negative regulation of transforming growth factor beta receptor signaling pathway
T cell costimulation
activation of protein kinase B activity
cellular response to insulin stimulus
negative regulation of toll-like receptor signaling pathway
intracellular signal transduction
Fc-epsilon receptor signaling pathway
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of mast cell degranulation
protein autophosphorylation
phosphatidylinositol-mediated signaling
focal adhesion assembly
T cell receptor signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
cellular response to epidermal growth factor stimulus
positive regulation of establishment of protein localization to plasma membrane
extrinsic apoptotic signaling pathway
purine nucleotide metabolic process
dGDP biosynthetic process
nucleobase-containing small molecule interconversion
GDP-mannose metabolic process
glycoprotein transport
ATP metabolic process
GMP metabolic process
dGMP metabolic process
dATP metabolic process
GDP biosynthetic process
nucleotide phosphorylation
negative regulation of transcription from RNA polymerase II promoter
positive regulation of autophagy
lipopolysaccharide-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
bicellular tight junction assembly

Function(s)

protein serine/threonine kinase activity
3-phosphoinositide-dependent protein kinase activity
insulin receptor binding
protein binding
ATP binding
phospholipase activator activity
kinase activity
protein kinase binding
phospholipase binding
guanylate kinase activity
RNA polymerase II transcription factor binding
transcription coactivator activity
double-stranded RNA binding
poly(A) RNA binding
NF-kappaB binding
DNA binding
metal ion binding