247259

Gene Symbol:

CFLAR FKSG49 NEK5 SPICE1 SQSTM1

Gene Name:

CASP8 and FADD like apoptosis regulator

FKSG49

NIMA related kinase 5

spindle and centriole associated protein 1

sequestosome 1

Gene Aliases:

CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS

FKSG52, FKSG55, FKSG56, FKSG57, FKSG60, FKSG61, FKSG64, FKSG65, FKSG66, FKSG67, FKSG68, FKSG70

-

CCDC52, SPICE

A170, FTDALS3, OSIL, PDB3, ZIP3, p60, p62, p62B

Chromosome Location:

Chr.2: 201116015 - 201172688 on Build GRCh38

Chromosome Location:

-

Chromosome Location:

Chr.13: 52064762 - 52129092 on Build GRCh38

Chromosome Location:

Chr.3: 113442718 - 113515187 on Build GRCh38

Chromosome Location:

Chr.5: 179806388 - 179838078 on Build GRCh38

UniGene ID:

Hs.390736

-

Hs.672144

Hs.477144

Hs.587290

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

-

-

siRNA Details

Gene Symbol: CFLAR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001127183.2	NP_001120655.1	10	4053
	NM_001202515.1	NP_001189444.1	6	3119
	NM_001202516.1	NP_001189445.1	8	3920
	NM_001202517.1	NP_001189446.1	9	3607
	NM_001202518.1	NP_001189447.1	8	4182
	NM_001202519.1	NP_001189448.1	9	4446
	NM_003879.5	NP_003870.4	10	4025
	XM_017005189.1	XP_016860678.1	11	4920
	XM_017005190.1	XP_016860679.1	10	3889
	XM_017005191.1	XP_016860680.1	10	3968
	XM_017005192.1	XP_016860681.1	10	4855
	XM_017005193.1	XP_016860682.1	10	6872
	XM_017005194.1	XP_016860683.1	10	4728
	XM_017005195.1	XP_016860684.1	11	4066
	XM_017005196.1	XP_016860685.1	8	3691

Gene Symbol: FKSG49
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AF336879.1	-	1	379
	AF336883.1	-	1	364
	AF336886.1	-	1	352
	AF338190.1	-	1	397
	AF338195.1	-	1	415
	AF338196.1	-	1	427
	AF338198.1	-	1	415
	AF469044.1	-	1	364

Gene Symbol: NEK5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AK126330.1	-	9	2720

Gene Symbol: SPICE1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AL832327.2	-	12	3200

Gene Symbol: SQSTM1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AK094484.1	-	1	89

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

proteolysis
apoptotic process
skeletal muscle tissue development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
viral process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
regulation of necroptotic process
execution phase of apoptosis
negative regulation of myoblast fusion
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

protease binding
death receptor binding
protein binding
enzyme activator activity
protein complex binding
cysteine-type endopeptidase activity involved in execution phase of apoptosis