2479

• Gene Symbol: PTGS2
• Gene Name: prostaglandin-endoperoxide synthase 2
• Gene Aliases: COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
• Chromosome Location: Chr.1: 186671812 - 186680427 on Build GRCh38
• UniGene ID: Hs.196384
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTGS2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000963.3	NP_000954.1	10	3929

More Information

Gene Ontology Categories:

Process(es)

prostaglandin biosynthetic process
angiogenesis
prostaglandin metabolic process
nicotinamide metabolic process
movement of cell or subcellular component
inflammatory response
response to oxidative stress
embryo implantation
learning
memory
regulation of blood pressure
negative regulation of cell proliferation
response to fructose
response to manganese ion
response to lithium ion
positive regulation of vascular endothelial growth factor production
sensory perception of pain
cyclooxygenase pathway
lipoxygenase pathway
bone mineralization
ovulation
positive regulation of prostaglandin biosynthetic process
positive regulation of fever generation
positive regulation of synaptic plasticity
negative regulation of synaptic transmission, dopaminergic
response to estradiol
response to lipopolysaccharide
response to vitamin D
response to tumor necrosis factor
cellular response to UV
maintenance of blood-brain barrier
positive regulation of NF-kappaB import into nucleus
response to drug
hair cycle
positive regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
negative regulation of cell cycle
positive regulation of vasoconstriction
negative regulation of smooth muscle contraction
positive regulation of smooth muscle contraction
decidualization
positive regulation of smooth muscle cell proliferation
regulation of inflammatory response
brown fat cell differentiation
response to glucocorticoid
negative regulation of calcium ion transport
positive regulation of synaptic transmission, glutamatergic
oxidation-reduction process
response to fatty acid
cellular response to mechanical stimulus
cellular response to ATP
cellular response to hypoxia
cellular response to fluid shear stress
positive regulation of transforming growth factor beta production
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of fibroblast growth factor production
positive regulation of brown fat cell differentiation
positive regulation of platelet-derived growth factor production
cellular oxidant detoxification

Function(s)

peroxidase activity
prostaglandin-endoperoxide synthase activity
protein binding
lipid binding
enzyme binding
heme binding
protein homodimerization activity
metal ion binding
arachidonate 15-lipoxygenase activity