251018

Gene Symbol:

CFLAR FKSG49 NEK5 ORC6

Gene Name:

CASP8 and FADD like apoptosis regulator

FKSG49

NIMA related kinase 5

origin recognition complex subunit 6

Gene Aliases:

CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS

FKSG52, FKSG55, FKSG56, FKSG57, FKSG60, FKSG61, FKSG64, FKSG65, FKSG66, FKSG67, FKSG68, FKSG70

-

ORC6L

Chromosome Location:

Chr.2: 201116015 - 201172688 on Build GRCh38

Chromosome Location:

-

Chromosome Location:

Chr.13: 52064762 - 52129092 on Build GRCh38

Chromosome Location:

Chr.16: 46689646 - 46698394 on Build GRCh38

UniGene ID:

Hs.390736

-

Hs.672144

Hs.49760

Species:

Human

Species Specific ID (Flybase ID):

-

-

-

-

siRNA Details

Gene Symbol: CFLAR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001127183.2	NP_001120655.1	10	3853
	NM_001202515.1	NP_001189444.1	6	2919
	NM_001202516.1	NP_001189445.1	8	3720
	NM_001202517.1	NP_001189446.1	9	3407
	NM_001202518.1	NP_001189447.1	8	3982
	NM_001202519.1	NP_001189448.1	9	4246
	NM_003879.5	NP_003870.4	10	3825
	XM_017005189.1	XP_016860678.1	11	4720
	XM_017005190.1	XP_016860679.1	10	3689
	XM_017005191.1	XP_016860680.1	10	3768
	XM_017005192.1	XP_016860681.1	10	4655
	XM_017005193.1	XP_016860682.1	10	6672
	XM_017005194.1	XP_016860683.1	10	4528
	XM_017005195.1	XP_016860684.1	11	3866
	XM_017005196.1	XP_016860685.1	8	3491

Gene Symbol: FKSG49
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AF336878.1	-	1	153
	AF336879.1	-	1	177
	AF336883.1	-	1	162
	AF336884.1	-	1	222
	AF336886.1	-	1	150
	AF336887.1	-	1	207
	AF338190.1	-	1	195
	AF338193.1	-	1	213
	AF338195.1	-	1	213
	AF338196.1	-	1	225
	AF338198.1	-	1	213
	AF338199.1	-	1	180
	AF469044.1	-	1	162

Gene Symbol: NEK5
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_199289.2	NP_954983.1	22	2859
GenBank mRNA	BC063885.1	-	22	2845	30383658

Gene Symbol: ORC6
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AK024077.1	-	4	1485

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

proteolysis
apoptotic process
skeletal muscle tissue development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
viral process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
regulation of necroptotic process
execution phase of apoptosis
negative regulation of myoblast fusion
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
protein phosphorylation
positive regulation of striated muscle cell differentiation
positive regulation of cysteine-type endopeptidase activity

Function(s)

protease binding
death receptor binding
protein binding
enzyme activator activity
protein complex binding
cysteine-type endopeptidase activity involved in execution phase of apoptosis
protein serine/threonine kinase activity
ATP binding
metal ion binding