251279

• Gene Symbol: Ripk2
• Gene Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
• Gene Aliases: 2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2
• Chromosome Location: Chr.4: 16122741 - 16163679 on Build GRCm38
• UniGene ID: Mm.112765
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ripk2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_138952.3	NP_620402.1	7	984
GenBank mRNA	AF461040.1	-	7	882
	AF487539.1	-	7	882
	AK159593.1	-	7	1008
	AK172319.1	-	7	1006
	AK172417.1	-	7	1006
	BC025611.1	-	5	502
	BC050845.1	-	7	998
	BC058088.1	-	7	1129
	BC069878.1	-	7	1009	5316066

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001191865, BC107468.

Gene Ontology Categories:

Process(es)

positive regulation of cytokine-mediated signaling pathway
adaptive immune response
immune system process
positive regulation of T-helper 1 type immune response
protein phosphorylation
apoptotic process
I-kappaB kinase/NF-kappaB signaling
positive regulation of peptidyl-threonine phosphorylation
phosphorylation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
positive regulation of immature T cell proliferation
positive regulation of peptidyl-serine phosphorylation
toll-like receptor 2 signaling pathway
toll-like receptor 4 signaling pathway
T cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to exogenous dsRNA
innate immune response
positive regulation of T-helper 1 cell differentiation
positive regulation of JNK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
response to interleukin-1
response to interleukin-12
response to interleukin-18
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to peptidoglycan
cellular response to muramyl dipeptide

Function(s)

nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
non-membrane spanning protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
LIM domain binding
protein homodimerization activity
CARD domain binding