42813

• Gene Symbol: ATM
• Gene Name: ATM serine/threonine kinase
• Gene Aliases: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
• Chromosome Location: Chr.11: 108222484 - 108369102 on Build GRCh38
• UniGene ID: Hs.367437
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ATM
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000051.3	NP_000042.3	4	678
	XM_005271561.4	XP_005271618.2	5	739
	XM_005271562.4	XP_005271619.2	4	812
	XM_006718843.3	XP_006718906.1	4	445
	XM_011542840.2	XP_011541142.1	5	533
	XM_011542842.2	XP_011541144.1	4	652
	XM_011542843.2	XP_011541145.1	4	1026
	XM_011542844.2	XP_011541146.1	4	650
	XM_017017789.1	XP_016873278.1	5	1236
	XM_017017790.1	XP_016873279.1	4	633
	XM_017017791.1	XP_016873280.1	4	1026
	XM_017017792.1	XP_016873281.1	4	1026
GenBank mRNA	AB209133.1	-	3	4816
	BC061584.1	-	4	481
	U33841.1	-	5	482
	X91196.1	-	4	1026

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
response to hypoxia
somitogenesis
pre-B cell allelic exclusion
DNA replication
DNA repair
double-strand break repair via nonhomologous end joining
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
telomere maintenance via telomerase
cell cycle arrest
mitotic spindle assembly checkpoint
reciprocal meiotic recombination
signal transduction
brain development
heart development
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to ionizing radiation
regulation of autophagy
histone phosphorylation
peptidyl-serine phosphorylation
negative regulation of B cell proliferation
positive regulation of telomere maintenance via telomerase
positive regulation of histone phosphorylation
V(D)J recombination
phosphatidylinositol-3-phosphate biosynthetic process
peptidyl-serine autophosphorylation
lipoprotein catabolic process
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of neuron apoptotic process
meiotic telomere clustering
protein autophosphorylation
oocyte development
neuron apoptotic process
regulation of telomerase activity
histone mRNA catabolic process
cellular response to gamma radiation
cellular response to X-ray
cellular response to nitrosative stress
signal transduction involved in mitotic G2 DNA damage checkpoint
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
regulation of cellular response to heat
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
negative regulation of telomere capping
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomerase catalytic core complex assembly

Function(s)

DNA binding
protein serine/threonine kinase activity
DNA-dependent protein kinase activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
protein complex binding
protein dimerization activity
protein N-terminus binding