46674

Gene Symbol:

Agtr1a Agtr1b

Gene Name:

angiotensin II receptor, type 1a

angiotensin II receptor, type 1b

Gene Aliases:

AT1, AT1A, AT1R, Agtr1

AT1, AT1B, AT3, AT₁R, Agtr1

Chromosome Location:

Chr.17: 35906084 - 35958132 on Build Rnor_6.0

Chromosome Location:

Chr.2: 105149020 - 105224342 on Build Rnor_6.0

UniGene ID:

Rn.9814

Rn.9815

Species:

Rat

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: Agtr1a
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_030985.4	NP_112247.2	3	379
	XM_006253882.2	XP_006253944.1	3	418
	XM_008771593.1	XP_008769815.1	2	335
	XM_008771594.1	XP_008769816.1	2	351
GenBank mRNA	BC078810.1	-	3	379	7126918
	M74054.1	-	3	374

Gene Symbol: Agtr1b
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_031009.2	NP_112271.2	2	280
	XM_006232186.2	XP_006232248.1	2	1450
	XM_006232187.2	XP_006232249.1	2	1364
	XM_008760878.1	XP_008759100.1	2	2024
	XM_008760879.1	XP_008759101.1	3	462
GenBank mRNA	M90065.1	-	2	311
	X64052.1	-	2	268

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_175086, NM_177322, BC109153, AK087228, BC036175.

• Set Membership: G-protein coupled receptor

Gene Ontology Categories:

Process(es)

blood vessel development
kidney development
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin secretion into blood stream
renin-angiotensin regulation of aldosterone production
regulation of renal output by angiotensin
brain renin-angiotensin system
regulation of pH
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
heart development
aging
regulation of blood pressure
positive regulation of cell proliferation
positive regulation of cholesterol esterification
regulation of vasoconstriction
calcium-mediated signaling
positive regulation of cellular protein metabolic process
positive regulation of phospholipase A2 activity
positive regulation of superoxide anion generation
regulation of smooth muscle cell apoptotic process
negative regulation of smooth muscle cell apoptotic process
angiotensin-activated signaling pathway
vasoconstriction
dopamine biosynthetic process
drinking behavior
activation of Janus kinase activity
negative regulation of neuron apoptotic process
response to estrogen
positive regulation of blood pressure
positive regulation of cytokine secretion
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cell chemotaxis
cellular response to dexamethasone stimulus
phospholipase C-activating angiotensin-activated signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
response to hypoxia
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
signal transduction
response to nutrient
response to immobilization stress
response to drug

Function(s)

angiotensin type I receptor activity
G-protein alpha-subunit binding
angiotensin type II receptor activity
protein binding
peptide hormone binding
protein kinase binding
bradykinin receptor binding
D1 dopamine receptor binding
protein self-association
protein heterodimerization activity
signal transducer activity
G-protein coupled receptor activity