53957

• Gene Symbol: Pten
• Gene Name: phosphatase and tensin homolog
• Gene Aliases: MMAC1, Mmac, TEP1
• Chromosome Location: Chr.1: 251421814 - 251487634 on Build Rnor_6.0
• UniGene ID: Rn.22158
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Pten
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_031606.1	NP_113794.1	2, 3	172
GenBank mRNA	AF017185.1	-	2, 3	172
	AF455569.1	-	2, 3	172

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_000314, CR450306, U92436, BC038293, AF019083, and others.
This siRNA also targets the following transcripts in Mouse: NM_008960, U92437, AK088717, BC021445, AK076980, and others.

Gene Ontology Categories:

Process(es)

angiogenesis
negative regulation of protein phosphorylation
regulation of B cell apoptotic process
protein dephosphorylation
neuron-neuron synaptic transmission
synapse assembly
central nervous system development
heart development
aging
response to nutrient
learning or memory
memory
locomotory behavior
positive regulation of cell proliferation
negative regulation of cell proliferation
response to glucose
response to organic substance
response to inorganic substance
response to zinc ion
regulation of neuron projection development
response to organic cyclic compound
dephosphorylation
cell migration
dentate gyrus development
central nervous system neuron axonogenesis
negative regulation of cell migration
neuron projection development
negative regulation of myelination
regulation of protein stability
negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
regulation of synaptic transmission, GABAergic
central nervous system myelin maintenance
response to estradiol
regulation of cellular component size
regulation of myeloid cell apoptotic process
response to ATP
multicellular organismal response to stress
social behavior
peptidyl-tyrosine dephosphorylation
cellular response to decreased oxygen levels
response to drug
maternal behavior
positive regulation of apoptotic process
negative regulation of apoptotic process
protein kinase B signaling
endothelial cell migration
response to ethanol
locomotor rhythm
negative regulation of cell size
negative regulation of organ growth
response to arsenic-containing substance
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
platelet-derived growth factor receptor signaling pathway
regulation of axon regeneration
cardiac muscle tissue development
forebrain morphogenesis
brain morphogenesis
negative regulation of epithelial cell proliferation
negative regulation of phagocytosis
negative regulation of axonogenesis
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of cell cycle
negative regulation of focal adhesion assembly
negative regulation of protein kinase B signaling
rhythmic synaptic transmission
canonical Wnt signaling pathway
synapse maturation
prepulse inhibition
male mating behavior
long-term synaptic potentiation
long term synaptic depression
prostate gland growth
dendritic spine morphogenesis
negative regulation of dendritic spine morphogenesis
positive regulation of ERK1 and ERK2 cascade
cellular response to hypoxia
negative regulation of ribosome biogenesis
negative regulation of cell aging
negative regulation of excitatory postsynaptic potential
presynaptic membrane assembly
postsynaptic density assembly
positive regulation of ubiquitin protein ligase activity
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of excitatory postsynaptic potential
negative regulation of synaptic vesicle clustering
positive regulation of apoptotic signaling pathway

Function(s)

magnesium ion binding
phosphatidylinositol-3-phosphatase activity
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
platelet-derived growth factor receptor binding
protein binding
protein tyrosine/serine/threonine phosphatase activity
anaphase-promoting complex binding
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
enzyme binding
protein kinase binding
PDZ domain binding
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity