57078

Gene Symbol:

Dkc1 LOC499971 Smarca4

Gene Name:

dyskeratosis congenita 1, dyskerin

similar to hypothetical protein 4931409K22

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Gene Aliases:

Nap57

Iqca1l, Iqca1p1

brg-1

Chromosome Location:

Chr.X: 155844914 - 155862764 on Build Rnor_6.0

Chromosome Location:

Chr.4: 7144674 - 7156300 on Build Rnor_6.0

Chromosome Location:

Chr.8: 22648323 - 22739468 on Build Rnor_6.0

UniGene ID:

Rn.4223

Rn.123098

Rn.23417

Species:

Rat

Species Specific ID (Flybase ID):

-

-

-

siRNA Details

Gene Symbol: Dkc1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_133419.1	NP_596910.1	14	1505
GenBank mRNA	BC087600.1	-	14	1464
	BC099832.1	-	14	1463	7934021
	Z34922.1	-	14	1505

Gene Symbol: LOC499971
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001024317.2	NP_001019488.2	19	2484
	XM_008762655.1	XP_008760877.1	18	2137
	XM_008762656.1	XP_008760878.1	17	2028
GenBank mRNA	BC079392.1	-	12	1420	7111961

Gene Symbol: Smarca4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_134368.1	NP_599195.1	10	2064
	XM_006242596.2	XP_006242658.1	10	2061
	XM_006242597.2	XP_006242659.1	10	2061
	XM_006242598.2	XP_006242660.1	10	2061
	XM_006242599.2	XP_006242661.1	10	2061
	XM_006242600.2	XP_006242662.1	10	2061
	XM_006242601.2	XP_006242663.1	10	2061
GenBank mRNA	AJ504723.1	-	9	1742

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_011417, NM_177676, NM_001174078, NM_001174079, BC145792, and others.

Gene Ontology Categories:

Process(es)

pseudouridine synthesis
RNA-dependent DNA biosynthetic process
rRNA processing
RNA processing
cell proliferation
rRNA pseudouridine synthesis
positive regulation of telomere maintenance via telomerase
box H/ACA snoRNA metabolic process
positive regulation of telomerase activity
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
neural retina development
nucleosome disassembly
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
spermatid development
nervous system development
glial cell fate determination
heart development
positive regulation of cell proliferation
DNA methylation on cytosine within a CG sequence
stem cell population maintenance
neurogenesis
positive regulation of Wnt signaling pathway
extracellular matrix organization
keratinocyte differentiation
negative regulation of cell growth
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation by host of viral transcription
histone H3 acetylation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
epidermis morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
definitive erythrocyte differentiation
heart trabecula formation
negative regulation of androgen receptor signaling pathway
pharyngeal arch artery morphogenesis
lens fiber cell development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter

Function(s)

telomerase activity
RNA binding
protein binding
pseudouridine synthase activity
poly(A) RNA binding
ATP binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
helicase activity
DNA-dependent ATPase activity
transcription factor binding
ATPase activity
Tat protein binding
nucleosomal DNA binding
protein complex binding
histone binding
protein N-terminus binding
androgen receptor binding
DNA polymerase binding
lysine-acetylated histone binding