59047

Gene Symbol:

Egln1 LOC690182

Gene Name:

egl-9 family hypoxia-inducible factor 1

similar to Egl nine homolog 1 (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (SM-20)

Gene Aliases:

HIF-PH2, HPH-2, PHD-2, PHD2

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Chromosome Location:

Chr.19: 57660194 - 57701158 on Build Rnor_6.0

Chromosome Location:

Chr.1: 173283884 - 173291061 on Build Rnor_6.0

UniGene ID:

Rn.232203

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Species:

Rat

Species Specific ID (Flybase ID):

-

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siRNA Details

Gene Symbol: Egln1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_008772679.1	XP_008770901.1	4, 5	1631
GenBank mRNA	AY228140.1	-	2, 3	416
	BC081694.1	-	2, 3	660

Gene Symbol: LOC690182
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_008759848.1	XP_008758070.1	1	656

More Information

Gene Ontology Categories:

Process(es)

response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
negative regulation of cAMP catabolic process
oxygen homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of angiogenesis
negative regulation of cyclic-nucleotide phosphodiesterase activity
cardiac muscle tissue morphogenesis
oxidation-reduction process
heart trabecula formation
ventricular septum morphogenesis
labyrinthine layer development
response to nitric oxide

Function(s)

iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
enzyme binding
L-ascorbic acid binding
peptidyl-proline dioxygenase activity
peptidyl-proline 4-dioxygenase activity