6222

• Gene Symbol: MCL1
• Gene Name: BCL2 family apoptosis regulator
• Gene Aliases: BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
• Chromosome Location: Chr.1: 150574551 - 150579738 on Build GRCh38
• UniGene ID: Hs.632486
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MCL1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001197320.1	NP_001184249.1	2, 3	445
	NM_021960.4	NP_068779.1	1, 2	904
GenBank mRNA	AF118124.1	-	1, 2	745
	AF118276.1	-	1, 2	154
	AF118277.1	-	1, 2	154
	AF118278.1	-	1, 2	154
	AK294462.1	-	2, 3	476
	AK297217.1	-	2, 3	440
	AK300499.1	-	2, 3	550
	AK304775.1	-	2, 3	586
	AK312508.1	-	1, 2	776
	AK316267.1	-	2, 3	732
	BC017197.2	-	1, 2	750	3138465
	BC071897.1	-	1, 2	752	6586159
	BC107735.1	-	1, 2	767	4770487
	BT006640.1	-	1, 2	696
	L08246.1	-	1, 2	756

More Information

Additional Information:

This siRNA no longer meets our design criteria. We suggest you choose a different siRNA for this gene or contact Tech Support for more information.

Gene Ontology Categories:

Process(es)

cell fate determination
multicellular organism development
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
cellular homeostasis
response to cytokine
negative regulation of apoptotic process
protein transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of anoikis
regulation of response to DNA damage stimulus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

protein binding
protein channel activity
protein homodimerization activity
protein heterodimerization activity
BH3 domain binding