66575

• Gene Symbol: Edn1
• Gene Name: endothelin 1
• Gene Aliases: ET-1, preproET
• Chromosome Location: Chr.13: 42301270 - 42307989 on Build GRCm38
• UniGene ID: Mm.14543
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Edn1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_010104.3	NP_034234.1	2	816
GenBank mRNA	AB081657.1	-	2	202
	AK040778.1	-	2	474
	AK152647.1	-	2	467
	AK153437.1	-	2	471
	BC029547.1	-	2	610	5059522
	D43775.1	-	2	527
	U35233.1	-	2	221

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012548, M64711.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
prostaglandin biosynthetic process
patterning of blood vessels
response to hypoxia
in utero embryonic development
histamine secretion
regulation of systemic arterial blood pressure by endothelin
regulation of pH
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
cell-cell signaling
heart development
respiratory gaseous exchange
body fluid secretion
regulation of blood pressure
positive regulation of cell proliferation
dorsal/ventral pattern formation
positive regulation of heart rate
positive regulation of cardiac muscle hypertrophy
positive regulation of receptor biosynthetic process
neural crest cell development
phosphatidylinositol 3-kinase signaling
artery smooth muscle contraction
vein smooth muscle contraction
glucose transport
cell growth
regulation of vasoconstriction
sensory perception of pain
calcium-mediated signaling
peptide hormone secretion
nitric oxide transport
positive regulation of cell migration
negative regulation of cAMP biosynthetic process
phospholipase D-activating G-protein coupled receptor signaling pathway
negative regulation of cellular protein metabolic process
positive regulation of prostaglandin secretion
negative regulation of smooth muscle cell apoptotic process
intracellular signal transduction
positive regulation of urine volume
positive regulation of renal sodium excretion
epithelial fluid transport
vasoconstriction
protein kinase C deactivation
middle ear morphogenesis
positive regulation of odontogenesis
superoxide anion generation
rhythmic excitation
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
positive regulation of cell size
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
positive regulation of hormone secretion
negative regulation of hormone secretion
inositol phosphate-mediated signaling
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of blood vessel size
cartilage development
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
negative regulation of nitric-oxide synthase biosynthetic process
membrane depolarization
regulation of sensory perception of pain
positive regulation of sarcomere organization
positive regulation of prostaglandin-endoperoxide synthase activity
positive regulation of neutrophil chemotaxis

Function(s)

receptor binding
cytokine activity
hormone activity
protein binding
endothelin A receptor binding
endothelin B receptor binding