69457

• Gene Symbol: Stat3
• Gene Name: signal transducer and activator of transcription 3
• Gene Aliases: 1110034C02Rik, AW109958, Aprf
• Chromosome Location: Chr.11: 100886810 - 100939570 on Build GRCm38
• UniGene ID: Mm.249934
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Stat3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011486.4	NP_035616.1	5, 6	755
	NM_213659.2	NP_998824.1	5, 6	755
	NM_213660.2	NP_998825.1	5, 6	755
GenBank mRNA	AK145486.1	-	5, 6	611
	AK153005.1	-	5, 6	667
	AK153472.1	-	5, 6	667
	AY299489.1	-	4, 5	482
	AY299490.1	-	4, 5	482
	BC003806.1	-	5, 6	643	3593588
	BC019168.1	-	5, 6	659	4923137
	L29278.1	-	5, 6	734
	U06922.1	-	5, 6	544
	U08378.1	-	5, 6	622
	U30709.1	-	5, 6	648

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_003150, NM_213662, NM_139276, L29277, AK297994, and others.
This siRNA also targets the following transcripts in Rat: NM_012747, XM_006247258, XM_006247257, XM_006247259, X91810, and others.

Gene Ontology Categories:

Process(es)

temperature homeostasis
eye photoreceptor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein import into nucleus
acute-phase response
signal transduction
JAK-STAT cascade
cell proliferation
negative regulation of cell proliferation
negative regulation of hydrogen peroxide biosynthetic process
phosphorylation
cytokine-mediated signaling pathway
stem cell population maintenance
sexual reproduction
intracellular receptor signaling pathway
response to estradiol
cellular response to hormone stimulus
response to cytokine
regulation of multicellular organism growth
glucose homeostasis
eating behavior
negative regulation of apoptotic process
positive regulation of Notch signaling pathway
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of mitochondrial membrane permeability
astrocyte differentiation
radial glial cell differentiation
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of cell death
interleukin-6-mediated signaling pathway
negative regulation of neuron death
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
positive regulation of ATP biosynthetic process
negative regulation of neuron migration

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
protein phosphatase binding
CCR5 chemokine receptor binding
glucocorticoid receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity