77

• Gene Symbol: ACVR1
• Gene Name: activin A receptor type 1
• Gene Aliases: ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
• Chromosome Location: Chr.2: 157736446 - 157875880 on Build GRCh38
• UniGene ID: Hs.470316
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ACVR1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001105.4	NP_001096.1	11	2340
	NM_001111067.2	NP_001104537.1	11	2159
	XM_005246939.3	XP_005246996.1	11	2211
	XM_005246940.3	XP_005246997.1	11	2179
	XM_006712825.3	XP_006712888.1	11	2292
	XM_011512106.2	XP_011510408.1	12	2259
	XM_011512107.2	XP_011510409.1	11	2231
	XM_011512108.2	XP_011510410.1	11	3638
GenBank mRNA	BC033867.1	-	11	2340	5209711
	BC036748.1	-	11	2340
	Z22534.1	-	10	2013

More Information

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
patterning of blood vessels
in utero embryonic development
gastrulation with mouth forming second
mesoderm formation
neural crest cell migration
acute inflammatory response
embryonic heart tube morphogenesis
outflow tract septum morphogenesis
atrioventricular valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
endocardial cushion fusion
atrial septum primum morphogenesis
protein phosphorylation
transforming growth factor beta receptor signaling pathway
germ cell development
determination of left/right symmetry
negative regulation of signal transduction
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
regulation of ossification
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
activin receptor signaling pathway
negative regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
pharyngeal system development
pathway-restricted SMAD protein phosphorylation
ventricular septum morphogenesis
cardiac muscle cell fate commitment
BMP signaling pathway involved in heart development
endocardial cushion cell fate commitment
cellular response to glucocorticoid stimulus
cellular response to BMP stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of determination of dorsal identity
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
peptide hormone binding
protein homodimerization activity
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding