859

• Gene Symbol: IRAK3
• Gene Name: interleukin 1 receptor associated kinase 3
• Gene Aliases: ASRT5, IRAKM
• Chromosome Location: Chr.12: 66189198 - 66254622 on Build GRCh38
• UniGene ID: Hs.369265
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: IRAK3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_007199.2	NP_009130.2	2	303
GenBank mRNA	AF113136.1	-	2	264
	AK314040.1	-	2	285
	BC057800.1	-	2	278	30335802
	BC069388.1	-	2	251	7262303
	BP292474.1	-	1	234

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108101, BC166731.
This siRNA also targets the following transcripts in Mouse: NM_028679, AF461763, AK014783, BC120829, AJ440757, and others.

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
protein phosphorylation
response to virus
positive regulation of macrophage tolerance induction
negative regulation of macrophage cytokine production
cytokine-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to peptidoglycan
response to lipopolysaccharide
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
negative regulation of protein catabolic process
negative regulation of protein complex disassembly
regulation of protein complex disassembly
response to exogenous dsRNA
negative regulation of MAP kinase activity
negative regulation of innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
response to interleukin-1

Function(s)

magnesium ion binding
protein serine/threonine kinase activity
ATP binding
protein homodimerization activity
protein heterodimerization activity