8857

• Gene Symbol: NOS2
• Gene Name: nitric oxide synthase 2
• Gene Aliases: HEP-NOS, INOS, NOS, NOS2A
• Chromosome Location: Chr.17: 27756766 - 27804339 on Build GRCh38
• UniGene ID: Hs.709191
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: NOS2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000625.4	NP_000616.3	5, 6	740
	XM_011524859.2	XP_011523161.1	5, 6	766
	XM_011524860.2	XP_011523162.1	4, 5	559
	XM_011524861.1	XP_011523163.1	5, 6	738
GenBank mRNA	AB022318.1	-	4, 5	476
	AF068236.1	-	5, 6	710
	AK304252.1	-	5, 6	738
	BC130283.1	-	5, 6	660	40146314
	BC144126.1	-	5, 6	660	9052646
	D26525.1	-	4, 5	490
	L09210.1	-	5, 6	682
	L24553.1	-	4, 5	552
	S76479.1	-	1, 2	163
	U05810.1	-	5, 6	670
	U20141.1	-	4, 5	476
	U31511.1	-	5, 6	581
	X73029.1	-	5, 6	701

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012611, XM_006246949, D14051, U26686, AY211532, and others.
This siRNA also targets the following transcripts in Mouse: NM_010927, M92649, AY090567, AF065923, M87039, and others.

Gene Ontology Categories:

Process(es)

response to hypoxia
positive regulation of leukocyte mediated cytotoxicity
innate immune response in mucosa
arginine catabolic process
superoxide metabolic process
nitric oxide biosynthetic process
nitric oxide mediated signal transduction
circadian rhythm
response to bacterium
negative regulation of gene expression
peptidyl-cysteine S-nitrosylation
positive regulation of guanylate cyclase activity
prostaglandin secretion
cellular response to drug
regulation of cell proliferation
negative regulation of protein catabolic process
defense response to bacterium
regulation of cellular respiration
cell redox homeostasis
negative regulation of blood pressure
positive regulation of vasodilation
regulation of insulin secretion
defense response to Gram-negative bacterium
positive regulation of killing of cells of other organism
oxidation-reduction process
cellular response to lipopolysaccharide
cellular response to interferon-gamma
interleukin-6 secretion
interleukin-8 secretion
regulation of cytokine production involved in inflammatory response

Function(s)

nitric-oxide synthase activity
receptor binding
protein binding
calmodulin binding
FMN binding
heme binding
tetrahydrobiopterin binding
arginine binding
protein homodimerization activity
metal ion binding
flavin adenine dinucleotide binding
NADP binding