HSS110547

• Gene Symbol: TCF7L2
• Gene Name: transcription factor 7 like 2
• Gene Aliases: TCF-4, TCF4
• Chromosome Location: Chr.10: 112950219 - 113167678 on Build GRCh38
• UniGene ID: Hs.593995
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TCF7L2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001146274.1	NP_001139746.1	14	1960
	NM_001146283.1	NP_001139755.1	13	1959
	NM_001146284.1	NP_001139756.1	13	1857
	NM_001146285.1	NP_001139757.1	13	1891
	NM_001146286.1	NP_001139758.1	12	1818
	NM_001198525.1	NP_001185454.1	15	2030
	NM_001198526.1	NP_001185455.1	13	1891
	NM_001198527.1	NP_001185456.1	15	1955
	NM_001198528.1	NP_001185457.1	15	1967
	NM_001198529.1	NP_001185458.1	13	1869
	NM_001198530.1	NP_001185459.1	11	1716
	NM_001198531.1	NP_001185460.1	13	1887
	NM_030756.4	NP_110383.2	14	1942
	XM_005270071.1	XP_005270128.1	16	2201
	XM_005270075.1	XP_005270132.1	16	2186
	XM_005270077.1	XP_005270134.1	15	2150
	XM_005270078.1	XP_005270135.1	15	2150
	XM_005270079.1	XP_005270136.1	15	2135
	XM_005270080.1	XP_005270137.1	15	2132
	XM_005270084.1	XP_005270141.1	15	2042
	XM_005270085.1	XP_005270142.1	14	2006
	XM_005270086.1	XP_005270143.1	14	1988
	XM_005270088.1	XP_005270145.1	14	1961
	XM_005270089.1	XP_005270146.1	13	1937
	XM_005270091.2	XP_005270148.1	17	2274
	XM_005270093.2	XP_005270150.1	15	2128
	XM_005270094.2	XP_005270151.1	15	2125
	XM_005270095.1	XP_005270152.1	14	2077
	XM_005270096.2	XP_005270153.1	14	1969
	XM_005270100.1	XP_005270157.1	13	1933
	XM_005270101.2	XP_005270158.1	13	1915
	XM_005270102.1	XP_005270159.1	13	1906
	XM_005270103.1	XP_005270160.1	12	1864
	XM_005270104.1	XP_005270161.1	12	1837
	XM_011540109.1	XP_011538411.1	16	2201
	XM_011540110.1	XP_011538412.1	15	2105
	XM_011540111.1	XP_011538413.1	14	1973
	XM_011540116.1	XP_011538418.1	16	2223
	XM_017016584.1	XP_016872073.1	16	2198
	XM_017016585.1	XP_016872074.1	16	2189
	XM_017016586.1	XP_016872075.1	16	2186
	XM_017016587.1	XP_016872076.1	16	2174
	XM_017016588.1	XP_016872077.1	15	2132
	XM_017016589.1	XP_016872078.1	14	2078
	XM_017016590.1	XP_016872079.1	15	2057
	XM_017016591.1	XP_016872080.1	15	2045
	XM_017016592.1	XP_016872081.1	15	2042
	XM_017016593.1	XP_016872082.1	14	1991
	XM_017016594.1	XP_016872083.1	14	1988
	XM_017016595.1	XP_016872084.1	14	2062
	XM_017016596.1	XP_016872085.1	14	1957
GenBank mRNA	AB440195.1	-	13	1380
	AB451266.1	-	14	1435
	AK074705.1	-	4	333
	AK225809.1	-	13	1895
	AK299295.1	-	12	1348
	AK301483.1	-	11	1158
	AK315243.1	-	13	1625
	AK316111.1	-	12	1045
	BC032656.1	-	13	1446	5533185
	CR536574.1	-	14	1435
	FJ010164.1	-	13	1330
	FJ010165.1	-	14	1462
	FJ010166.1	-	15	1616
	FJ010167.1	-	13	1477
	FJ010170.1	-	13	1455
	FJ010171.1	-	11	1246
	FJ010172.1	-	12	1408
	FJ010173.1	-	13	1330
	FJ010174.1	-	14	1839
	HM352838.1	-	13	1377
	HM352839.1	-	13	1399
	HM352841.1	-	13	1395
	HM352842.1	-	12	1311
	HM352843.1	-	12	1299
	HM352844.1	-	14	1431
	HM352845.1	-	15	1564
	HM352846.1	-	13	1380
	HM352847.1	-	13	1384
	HM352848.1	-	14	1435
	HM352849.1	-	12	1326
	HM352850.1	-	15	1504
	HM352851.1	-	14	1468
	Y11306.2	-	14	1742

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001191052.
This siRNA also targets the following transcripts in Mouse: NM_001142919, NM_001142922, NM_009333, NM_001142918, NM_001142923, and others.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Wnt signaling pathway, calcium modulating pathway
cell proliferation
response to glucose
positive regulation of heparan sulfate proteoglycan biosynthetic process
pancreas development
positive regulation of insulin secretion
positive regulation of protein binding
regulation of hormone metabolic process
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
maintenance of DNA repeat elements
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
myoblast fate commitment
regulation of smooth muscle cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
protein kinase binding
nuclear hormone receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding