HSS177102

• Gene Symbol: KDM1A
• Gene Name: lysine demethylase 1A
• Gene Aliases: AOF2, BHC110, CPRF, KDM1, LSD1
• Chromosome Location: Chr.1: 23019443 - 23083691 on Build GRCh38
• UniGene ID: Hs.591518
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: KDM1A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001009999.2	NP_001009999.1	17	2185
	NM_015013.3	NP_055828.2	15	2113
	XM_005245786.2	XP_005245843.1	16	2178
	XM_006710472.3	XP_006710535.1	15	2136
	XM_006710473.2	XP_006710536.1	16	2196
	XM_006710474.3	XP_006710537.1	16	2196
	XM_017000716.1	XP_016856205.1	16	2178
	XM_017000717.1	XP_016856206.1	15	2118
	XM_017000718.1	XP_016856207.1	14	1602
	XM_017000719.1	XP_016856208.1	15	1728
	XM_017000720.1	XP_016856209.1	14	1698
GenBank mRNA	AB011173.1	-	15	2066
	AK290328.1	-	15	1639
	AL833812.1	-	11	1235
	BC016639.1	-	13	1352
	BC025362.1	-	7	778
	BC040194.2	-	17	2140	4815528
	BC048134.1	-	15	2034	5298150

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001130098, EF688598.
This siRNA also targets the following transcripts in Mouse: NM_133872, BC019417, BC059885, AK007763, AK129170.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein demethylation
blood coagulation
cell proliferation
regulation of double-strand break repair via homologous recombination
regulation of primitive erythrocyte differentiation
histone deacetylation
pituitary gland development
granulocyte differentiation
negative regulation of protein binding
histone H3-K9 demethylation
positive regulation of histone ubiquitination
cellular response to UV
histone H3-K4 demethylation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of erythrocyte differentiation
positive regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone biosynthetic process
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
muscle cell development
oxidation-reduction process
cellular response to gamma radiation
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of cellular protein localization
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation

Function(s)

RNA polymerase II transcription factor binding
p53 binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
oxidoreductase activity
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
demethylase activity
histone demethylase activity
histone demethylase activity (H3-K4 specific)
histone demethylase activity (H3-K9 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
telomeric DNA binding
MRF binding
transcription regulatory region DNA binding
flavin adenine dinucleotide binding
androgen receptor binding
telomeric repeat-containing RNA binding