HSS188721

Gene Symbol:

PICALM MLLT10

Gene Name:

phosphatidylinositol binding clathrin assembly protein

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10

Gene Aliases:

CALM, CLTH, LAP

AF10

Chromosome Location:

Chr.11: 85957171 - 86069881 on Build GRCh38

Chromosome Location:

Chr.10: 21533349 - 21743630 on Build GRCh38

UniGene ID:

Hs.163893

Hs.30385

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: PICALM
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001008660.2	NP_001008660.1	19	2081
	NM_001206946.1	NP_001193875.1	19	2186
	NM_001206947.1	NP_001193876.1	18	1772
	NM_007166.3	NP_009097.2	19	2207
	XM_005274322.2	XP_005274379.1	20	2215
	XM_005274323.2	XP_005274380.1	20	2200
	XM_005274324.2	XP_005274381.1	19	2191
	XM_005274325.2	XP_005274382.1	19	2176
	XM_005274326.2	XP_005274383.1	20	2215
	XM_005274327.2	XP_005274384.1	18	2131
	XM_005274328.2	XP_005274385.1	20	2200
	XM_005274329.3	XP_005274386.1	19	2176
	XM_005274330.2	XP_005274387.1	19	2065
	XM_005274331.2	XP_005274388.1	18	2131
	XM_005274332.2	XP_005274389.1	19	2050
	XM_005274333.2	XP_005274390.1	18	2041
	XM_005274334.2	XP_005274391.1	18	2116
	XM_005274335.2	XP_005274392.1	18	2026
	XM_005274336.2	XP_005274393.1	19	2050
	XM_006718699.2	XP_006718762.1	20	2194
	XM_006718700.2	XP_006718763.1	20	2179
	XM_006718701.3	XP_006718764.1	19	2170
	XM_011545293.1	XP_011543595.1	18	1957
	XM_017018381.1	XP_016873870.1	20	2179
	XM_017018382.1	XP_016873871.1	17	1981
	XM_017018383.1	XP_016873872.1	18	2041
	XM_017018384.1	XP_016873873.1	18	2026
	XM_017018386.1	XP_016873875.1	17	1981
	XM_017018387.1	XP_016873876.1	17	1966
	XM_017018388.1	XP_016873877.1	18	1957
GenBank mRNA	AB210017.1	-	19	2186
	AB451308.1	-	19	1764
	AF060939.1	-	3	168
	AF060940.1	-	2	108
	AK291414.1	-	20	2074
	AK297062.1	-	11	951
	AK300275.1	-	18	1749
	BC048259.1	-	19	1968	5537605
	BC064357.1	-	19	2043	5112878
	BC073961.1	-	19	1917	6183858
	EF051633.1	-	3	203
	U45976.1	-	19	2037

Gene Symbol: MLLT10
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
GenBank mRNA	AF060929.1	-		239

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_053554, XM_006229676, XM_006229674, XM_006229681, XM_006229679, and others.
This siRNA also targets the following transcripts in Mouse: NM_001252521, NM_001252524, NM_001252523, NM_146194, NM_001252520, and others.

Gene Ontology Categories:

Process(es)

protein complex assembly
receptor-mediated endocytosis
cell proliferation
negative regulation of gene expression
synaptic vesicle maturation
vesicle-mediated transport
endosomal transport
regulation of endocytosis
receptor internalization
regulation of protein localization
cargo loading into vesicle
positive regulation of transcription, DNA-templated
negative regulation of receptor-mediated endocytosis
clathrin coat assembly
iron ion homeostasis
clathrin-mediated endocytosis
iron ion import into cell
cell-cell adhesion
positive regulation of neuron death
positive regulation of beta-amyloid formation
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Function(s)

protein binding
1-phosphatidylinositol binding
clathrin binding
clathrin heavy chain binding
clathrin adaptor activity
cadherin binding involved in cell-cell adhesion