RSS339200

• Gene Symbol: Runx2
• Gene Name: runt-related transcription factor 2
• Gene Aliases: Cbfa1, OSF-2
• Chromosome Location: Chr.9: 18564748 - 18773092 on Build Rnor_6.0
• UniGene ID: Rn.83672
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Runx2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001278483.1	NP_001265412.1	6	1072
	XM_006244549.2	XP_006244611.1	5	1273
	XM_006244550.2	XP_006244612.1	6	1284
	XM_006244551.2	XP_006244613.1	6	1251

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_001015051, NM_001024630, NM_001278478, L40992, BC108919, and others.
This siRNA also targets the following transcripts in Mouse: NM_001271627, NM_001145920, NM_009820, NM_001146038, D14636, and others.

Gene Ontology Categories:

Process(es)

skeletal system development
osteoblast differentiation
endochondral ossification
osteoblast fate commitment
chondrocyte differentiation
chondrocyte development
osteoblast development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
positive regulation of gene expression
T cell differentiation
regulation of ossification
BMP signaling pathway
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
regulation of fibroblast growth factor receptor signaling pathway
odontogenesis of dentin-containing tooth
regulation of odontogenesis of dentin-containing tooth
cellular response to fibroblast growth factor stimulus
regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
stem cell differentiation
cellular response to BMP stimulus
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
ATP binding
transcription factor binding
protein domain specific binding
histone deacetylase binding
bHLH transcription factor binding
transcription regulatory region DNA binding
repressing transcription factor binding