RSS358682

• Gene Symbol: Rapgef2
• Gene Name: Rap guanine nucleotide exchange factor (GEF) 2
• Gene Aliases: PDZ-GEF1, RA-GEF-1, nRap GEP
• Chromosome Location: Chr.2: 177836191 - 178057397 on Build Rnor_6.0
• UniGene ID: Rn.23121
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Rapgef2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001107684.1	NP_001101154.1	18	3273
	XM_006232511.2	XP_006232573.2	23	5185
	XM_006232512.2	XP_006232574.1	21	4251
	XM_006232513.2	XP_006232575.1	21	4062
	XM_008761092.1	XP_008759314.1	27	4555
	XM_008761093.1	XP_008759315.1	26	4538
	XM_008761094.1	XP_008759316.1	26	4531
	XM_008761095.1	XP_008759317.1	27	4229
	XM_008761096.1	XP_008759318.1	25	4844
	XM_008761097.1	XP_008759319.1	24	4736
	XM_008761098.1	XP_008759320.1	24	6028

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001099624, BC067056, AK147368, AB093228.

Gene Ontology Categories:

Process(es)

blood vessel development
neuron migration
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
small GTPase mediated signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
cAMP-mediated signaling
ventricular system development
forebrain neuron development
microvillus assembly
neuron projection development
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of protein binding
Rap protein signal transduction
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
positive regulation of protein kinase activity
negative regulation of melanin biosynthetic process
regulation of synaptic plasticity
negative regulation of dendrite morphogenesis
regulation of small GTPase mediated signal transduction
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to cGMP
adenylate cyclase-activating adrenergic receptor signaling pathway
protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
positive regulation of cAMP-dependent protein kinase activity
positive regulation of dendritic cell apoptotic process
positive regulation of vasculogenesis
positive regulation of neuron migration

Function(s)

guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
Rap guanyl-nucleotide exchange factor activity
protein kinase binding
PDZ domain binding
cAMP binding
cGMP binding
beta-1 adrenergic receptor binding
WW domain binding
phosphatidic acid binding