s11485 Validated

• Gene Symbol: PTK2
• Gene Name: protein tyrosine kinase 2
• Gene Aliases: FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
• Chromosome Location: Chr.8: 140658382 - 141001313 on Build GRCh38
• UniGene ID: Hs.395482
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001199649.1	NP_001186578.1	8	916
	NM_001316342.1	NP_001303271.1	6	660
	NM_005607.4	NP_005598.3	8	905
	NM_153831.3	NP_722560.1	8	916
	XM_005251003.2	XP_005251060.1	7	957
	XM_005251012.2	XP_005251069.1	7	799
	XM_005251013.2	XP_005251070.1	6	618
	XM_006716608.2	XP_006716671.1	8	888
	XM_006716609.2	XP_006716672.1	7	721
	XM_006716610.2	XP_006716673.1	7	713
	XM_011517194.2	XP_011515496.1	8	857
	XM_017013651.1	XP_016869140.1	6	638
	XM_017013652.1	XP_016869141.1	6	638
	XM_017013653.1	XP_016869142.1	7	957
	XM_017013654.1	XP_016869143.1	7	957
	XM_017013655.1	XP_016869144.1	7	957
	XM_017013656.1	XP_016869145.1	7	957
	XM_017013657.1	XP_016869146.1	7	957
	XM_017013658.1	XP_016869147.1	8	781
	XM_017013659.1	XP_016869148.1	6	638
	XM_017013660.1	XP_016869149.1	8	781
	XM_017013661.1	XP_016869150.1	7	799
	XM_017013662.1	XP_016869151.1	8	781
	XM_017013663.1	XP_016869152.1	7	712
	XM_017013664.1	XP_016869153.1	8	888
	XM_017013665.1	XP_016869154.1	7	712
	XM_017013666.1	XP_016869155.1	7	957
	XM_017013667.1	XP_016869156.1	8	781
	XM_017013668.1	XP_016869157.1	7	799
	XM_017013669.1	XP_016869158.1	8	781
	XM_017013670.1	XP_016869159.1	8	781
	XM_017013671.1	XP_016869160.1	8	781
	XM_017013672.1	XP_016869161.1	7	712
	XM_017013673.1	XP_016869162.1	7	712
	XM_017013674.1	XP_016869163.1	8	888
	XM_017013675.1	XP_016869164.1	7	712
	XM_017013676.1	XP_016869165.1	6	638
	XM_017013677.1	XP_016869166.1	8	781
	XM_017013678.1	XP_016869167.1	7	712
	XM_017013679.1	XP_016869168.1	7	712
	XM_017013680.1	XP_016869169.1	7	1773
	XM_017013681.1	XP_016869170.1	7	721
	XM_017013682.1	XP_016869171.1	6	618
	XM_017013683.1	XP_016869172.1	7	721
	XM_017013684.1	XP_016869173.1	7	721
	XM_017013685.1	XP_016869174.1	7	665
	XM_017013686.1	XP_016869175.1	6	618
	XM_017013687.1	XP_016869176.1	7	721
	XM_017013688.1	XP_016869177.1	7	721
	XM_017013689.1	XP_016869178.1	6	586
	XM_017013690.1	XP_016869179.1	6	560
GenBank mRNA	AB209071.1	-	6	566
	AB209083.1	-	8	503
	AK304356.1	-	8	761
	AL832961.1	-	8	788
	BC035404.2	-	6	637	4999680
	DA994616.1	-	6	519
	KF437463.1	-	6	609
	L13616.1	-	8	838

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013081, XM_008765546, AF020777, EV773243.
This siRNA also targets the following transcripts in Mouse: NM_001130409, NM_007982, AK079821, AB030035, AB011499, and others.

Matching Taqman Gene Expression Assay:

Hs00178587_m1

Gene Ontology Categories:

Process(es)

MAPK cascade
microtubule cytoskeleton organization
angiogenesis
vasculogenesis
neuron migration
placenta development
regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
cellular component disassembly involved in execution phase of apoptosis
signal complex assembly
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
axon guidance
positive regulation of cell proliferation
regulation of cell shape
embryo development
regulation of endothelial cell migration
regulation of epithelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
central nervous system neuron axonogenesis
negative regulation of cell-cell adhesion
establishment of cell polarity
extracellular matrix organization
positive regulation of cell migration
regulation of cell adhesion mediated by integrin
netrin-activated signaling pathway
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
establishment of nucleus localization
regulation of cell proliferation
negative regulation of apoptotic process
regulation of GTPase activity
endothelial cell migration
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of osteoblast differentiation
positive regulation of protein kinase activity
negative regulation of organ growth
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
cell motility
negative regulation of axonogenesis
regulation of cytoskeleton organization
regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of synapse assembly
growth hormone receptor signaling pathway
regulation of substrate adhesion-dependent cell spreading
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of anoikis

Function(s)

actin binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
ATP binding
JUN kinase binding
protein kinase binding
SH2 domain binding