s14071 Validated

• Gene Symbol: TGFBR1
• Gene Name: transforming growth factor beta receptor 1
• Gene Aliases: AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
• Chromosome Location: Chr.9: 99104038 - 99154192 on Build GRCh38
• UniGene ID: Hs.494622
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: TGFBR1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001130916.2	NP_001124388.1	6	1101
	NM_001306210.1	NP_001293139.1	7	1344
	NM_004612.3	NP_004603.1	7	1332
	XM_011518948.2	XP_011517250.1	7	1259
	XM_011518949.2	XP_011517251.1	7	1187
	XM_011518950.2	XP_011517252.1	6	4289
	XM_017015063.1	XP_016870552.1	7	1222
GenBank mRNA	AJ619019.2	-	7	1303
	AK302059.1	-	7	1218
	AK302234.1	-	7	1205
	BC071181.1	-	6	1079	30344890
	L11695.1	-	7	1291

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012775, XM_008763706, XM_006238153, XM_006238030, BC087035, and others.

Matching Taqman Gene Expression Assay:

Hs00610319_m1

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
skeletal system development
angiogenesis
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lens development in camera-type eye
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
proepicardium development
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
cell cycle arrest
signal transduction
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
germ cell migration
male gonad development
post-embryonic development
anterior/posterior pattern specification
regulation of epithelial to mesenchymal transition
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
collagen fibril organization
positive regulation of cell growth
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
activin receptor signaling pathway
intracellular signal transduction
wound healing
endothelial cell activation
extracellular structure organization
regulation of protein binding
endothelial cell migration
positive regulation of transcription, DNA-templated
thymus development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
mesenchymal cell differentiation
artery morphogenesis
cell motility
positive regulation of cellular component movement
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
coronary artery morphogenesis
response to cholesterol
cellular response to transforming growth factor beta stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of occluding junction disassembly
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
receptor signaling protein activity
type II transforming growth factor beta receptor binding
protein binding
ATP binding
growth factor binding
SMAD binding
metal ion binding
transforming growth factor beta binding
I-SMAD binding