s22119

• Gene Symbol: CHEK2
• Gene Name: checkpoint kinase 2
• Gene Aliases: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Chromosome Location: Chr.22: 28687743 - 28741866 on Build GRCh38
• UniGene ID: Hs.291363
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CHEK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005735.1	NP_001005735.1	6	831
	NM_001257387.1	NP_001244316.1	6	816
	NM_007194.3	NP_009125.1	5	702
	NM_145862.2	NP_665861.1	5	702
	XM_011529839.2	XP_011528141.1	6	853
	XM_011529840.2	XP_011528142.1	6	855
	XM_011529844.2	XP_011528146.1	6	863
	XM_011529845.2	XP_011528147.1	4	409
	XM_017028560.1	XP_016884049.1	6	817
	XM_017028561.1	XP_016884050.1	2	61
GenBank mRNA	AB040105.1	-	4	630
	AF086904.1	-	4	630
	AF096279.1	-	4	630
	AF174135.1	-	4	630
	AF217975.1	-	6	1415
	AJ131197.1	-	4	630
	AK289360.1	-	5	681
	AK290754.1	-	5	704
	AY551297.1	-	5	759
	AY551298.1	-	4	630
	AY551299.1	-	4	630
	AY551300.1	-	4	630
	AY551301.1	-	4	520
	AY551303.1	-	2	357
	AY551305.1	-	5	744
	BC004207.2	-	5	657	3532866
	CR456418.1	-	6	830

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_016681, BC056617, AK044913, AF086905.

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
G2/M transition of mitotic cell cycle
replicative cell aging
positive regulation of protein phosphorylation
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
peptidyl-serine phosphorylation
cellular response to drug
regulation of protein catabolic process
signal transduction in response to DNA damage
cellular protein catabolic process
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
negative regulation of cell cycle arrest
signal transduction involved in intra-S DNA damage checkpoint
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to doxorubicin
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis

Function(s)

protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding