s502495

• Gene Symbol: ACVRL1
• Gene Name: activin A receptor like type 1
• Gene Aliases: ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
• Chromosome Location: Chr.12: 51906913 - 51923361 on Build GRCh38
• UniGene ID: Hs.591026
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ACVRL1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000020.2	NP_000011.2	3	578
	NM_001077401.1	NP_001070869.1	2	441
	XM_005269235.2	XP_005269292.1	4	580
	XM_011539008.1	XP_011537310.1	2	436
GenBank mRNA	BC042637.1	-	2	327	5179243
	DN999570.1	-	3	586
	KU177888.1	-	2	295
	KU177889.1	-	2	295
	L17075.1	-	2	386
	Z22533.1	-	3	577

Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID	Transcript Location
GenBankmRNA	BI820840.1	-	2	348		Chr. 12 - 51912421 - 51914564 [+] on Build GRCh38
GenBankmRNA	AL525277.3	-	2	389		Chr. 12 - 51912385 - 51914074 [+] on Build GRCh38
GenBankmRNA	AL545599.3	-	2	437		Chr. 12 - 51912332 - 51915407 [+] on Build GRCh38
GenBankmRNA	BI822412.1	-	2	326		Chr. 12 - 51912443 - 51913763 [+] on Build GRCh38
GenBankmRNA	EL734253.1	-	2	295		Chr. 12 - 51912475 - 51914024 [+] on Build GRCh38
GenBankmRNA	AI017380.1	-	3	326		Chr. 12 - 51907670 - 51913759 [+] on Build GRCh38
GenBankmRNA	AI400112.1	-	3	377		Chr. 12 - 51907619 - 51913739 [+] on Build GRCh38
GenBankmRNA	AI740840.1	-	3	353		Chr. 12 - 51907643 - 51914081 [+] on Build GRCh38
GenBankmRNA	BI822484.1	-	2	326		Chr. 12 - 51912443 - 51914468 [+] on Build GRCh38
GenBankmRNA	AI149062.1	-	3	353		Chr. 12 - 51907643 - 51913670 [+] on Build GRCh38
GenBankmRNA	BP302249.1	-	2	440		Chr. 12 - 51912329 - 51914558 [+] on Build GRCh38
GenBankmRNA	CA406164.1	-	1	85		Chr. 12 - 51913248 - 51914494 [+] on Build GRCh38
GenBankmRNA	CD607151.1	-	1	247		Chr. 12 - 51913098 - 51913992 [+] on Build GRCh38
GenBankmRNA	BI770269.1	-	2	294		Chr. 12 - 51912476 - 51914072 [+] on Build GRCh38
GenBankmRNA	AI660167.1	-	3	359		Chr. 12 - 51907637 - 51913753 [+] on Build GRCh38
GenBankmRNA	AI277722.1	-	3	359		Chr. 12 - 51907636 - 51913658 [+] on Build GRCh38

More Information

Gene Ontology Categories:

Process(es)

angiogenesis
in utero embryonic development
regulation of endothelial cell proliferation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lymphangiogenesis
blood vessel maturation
blood vessel remodeling
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
endocardial cushion morphogenesis
regulation of DNA replication
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
blood circulation
regulation of blood pressure
negative regulation of cell proliferation
negative regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of chondrocyte differentiation
activin receptor signaling pathway
wound healing, spreading of epidermal cells
dorsal aorta morphogenesis
regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
negative regulation of endothelial cell differentiation
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein heterooligomerization
negative regulation of focal adhesion assembly
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
endothelial tube morphogenesis
retina vasculature development in camera-type eye
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
endocardial cushion to mesenchymal transition
negative regulation of DNA biosynthetic process

Function(s)

protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
activin receptor activity, type I
protein kinase binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta binding
BMP receptor activity