s6239 Validated

• Gene Symbol: GSK3B
• Gene Name: glycogen synthase kinase 3 beta
• Gene Aliases: -
• Chromosome Location: Chr.3: 119821321 - 120094417 on Build GRCh38
• UniGene ID: Hs.445733
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: GSK3B
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001146156.1	NP_001139628.1	9, 10	2082
	NM_002093.3	NP_002084.2	10, 11	2121
GenBank mRNA	AB451356.1	-	9, 10	1099
	AK290897.1	-	9, 10	1455
	BC000251.1	-	10, 11	1370	3357620
	BC012760.2	-	9, 10	2081	3637163
	CR536510.1	-	9, 10	1099
	EU302497.1	-	9, 10	1099
	L33801.1	-	9, 10	1138

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_032080, XM_006248375, XM_008768745, XM_006248373, XM_006248374, and others.
This siRNA also targets the following transcripts in Mouse: NM_019827, AK170965, BC006936, BC060743, AK154293, and others.

Matching Taqman Gene Expression Assay:

Hs00275656_m1

Gene Ontology Categories:

Process(es)

re-entry into mitotic cell cycle
epithelial to mesenchymal transition
positive regulation of cell-matrix adhesion
glycogen metabolic process
regulation of gene expression by genetic imprinting
protein phosphorylation
protein export from nucleus
ER overload response
dopamine receptor signaling pathway
axonogenesis
myoblast fusion
aging
circadian rhythm
organ morphogenesis
negative regulation of cardiac muscle hypertrophy
positive regulation of peptidyl-threonine phosphorylation
positive regulation of mitochondrial membrane potential
negative regulation of neuron maturation
response to activity
Wnt signaling pathway
cell migration
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
hippocampus development
establishment of cell polarity
negative regulation of protein complex assembly
positive regulation of protein complex assembly
negative regulation of protein binding
positive regulation of protein binding
response to estradiol
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to insulin
regulation of microtubule-based process
positive regulation of peptidyl-serine phosphorylation
negative regulation of smooth muscle cell apoptotic process
protein localization to microtubule
intracellular signal transduction
cellular response to hepatocyte growth factor stimulus
cellular response to interleukin-3
cellular response to erythropoietin
response to drug
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAP kinase activity
positive regulation of neuron apoptotic process
positive regulation of GTPase activity
hypermethylation of CpG island
canonical Wnt signaling pathway involved in positive regulation of apoptotic process
fat cell differentiation
negative regulation of glycogen biosynthetic process
positive regulation of protein catabolic process
positive regulation of axon extension
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
positive regulation of protein export from nucleus
regulation of neuronal synaptic plasticity
positive regulation of smooth muscle cell proliferation
negative regulation of dendrite morphogenesis
negative regulation of nitric-oxide synthase activity
negative regulation of NFAT protein import into nucleus
canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hydrogen peroxide
superior temporal gyrus development
cellular response to mechanical stimulus
cellular response to iron(II) ion
cellular response to lithium ion
response to epinephrine
negative regulation of canonical Wnt signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
chemical synaptic transmission, postsynaptic
regulation of cellular response to heat
negative regulation of protein localization to nucleus
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of neuron death
response to L-glutamate
cellular response to dopamine
negative regulation of dopaminergic neuron differentiation
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
response to insulin-like growth factor stimulus
response to ultrasound
response to angiotensin
negative regulation of type B pancreatic cell development
positive regulation of excitatory postsynaptic potential
negative regulation of glycogen (starch) synthase activity
positive regulation of DNA biosynthetic process
positive regulation of stem cell differentiation
negative regulation of neuron migration

Function(s)

RNA polymerase II transcription factor binding
p53 binding
protein kinase activity
protein serine/threonine kinase activity
integrin binding
protein binding
ATP binding
beta-catenin binding
kinase activity
protein kinase binding
ubiquitin protein ligase binding
protein kinase A catalytic subunit binding
ionotropic glutamate receptor binding
tau protein binding
tau-protein kinase activity
NF-kappaB binding