s74139

• Gene Symbol: Sorl1
• Gene Name: sortilin-related receptor, LDLR class A repeats-containing
• Gene Aliases: 2900010L19Rik, AI596264, AW261561, LR11, SorLA, gp250, mSorLA
• Chromosome Location: Chr.9: 41968489 - 42124289 on Build GRCm38
• UniGene ID: Mm.121920
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Sorl1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011436.3	NP_035566.2	31	4434
GenBank mRNA	AF031816.1	-		3712
	AK137635.1	-	19	2549
	AK147303.1	-	31	4435
	Y12004.1	-	8	904

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_003105, AK295878, AK316340, AK295090, BC137171, and others.

Gene Ontology Categories:

Process(es)

protein targeting to Golgi
protein targeting
protein targeting to lysosome
lipid metabolic process
transport
lipid transport
post-Golgi vesicle-mediated transport
endocytosis
multicellular organism development
steroid metabolic process
cholesterol metabolic process
regulation of smooth muscle cell migration
cell migration
negative regulation of protein binding
negative regulation of protein oligomerization
negative regulation of MAP kinase activity
protein retention in Golgi apparatus
positive regulation of protein catabolic process
negative regulation of neurogenesis
protein maturation
positive regulation of protein exit from endoplasmic reticulum
negative regulation of neuron death
negative regulation of beta-amyloid formation
positive regulation of choline O-acetyltransferase activity
negative regulation of tau-protein kinase activity
positive regulation of ER to Golgi vesicle-mediated transport
positive regulation of early endosome to recycling endosome transport
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of protein localization to early endosome
negative regulation of neurofibrillary tangle assembly
positive regulation of endocytic recycling

Function(s)

beta-amyloid binding
protein binding
low-density lipoprotein particle binding
ADP-ribosylation factor binding