s74840

• Gene Symbol: Tcf7l2
• Gene Name: transcription factor 7 like 2, T cell specific, HMG box
• Gene Aliases: TCF4B, TCF4E, Tcf-4, Tcf4, mTcf-4B, mTcf-4E
• Chromosome Location: Chr.19: 55741810 - 55933661 on Build GRCm38
• UniGene ID: Mm.139815
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Tcf7l2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001142918.1	NP_001136390.1	10	1721
	NM_001142919.1	NP_001136391.1	10	1721
	NM_001142920.1	NP_001136392.1	11	1793
	NM_001142921.1	NP_001136393.1	10	1736
	NM_001142922.1	NP_001136394.1	10	1721
	NM_001142923.1	NP_001136395.1	10	1721
	NM_001142924.1	NP_001136396.1	7	1023
	NM_009333.3	NP_033359.2	10	1721
GenBank mRNA	AF107298.1	-	10	1480
	AF107299.1	-	3	298
	AJ223070.1	-	10	1199
	AK035059.1	-	11	1621
	AK038720.1	-	10	1167
	AK048536.1	-	7	836
	AK052583.1	-	3	335
	AK132465.1	-	11	1707
	AY072035.1	-	10	1277
	BC009807.1	-	10	1226
	BC011397.1	-	10	1700
	BC052022.1	-	10	1300	5702449

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001191052.

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
cellular glucose homeostasis
glycogen metabolic process
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell cycle arrest
cell proliferation
cellular response to starvation
response to glucose
post-embryonic development
positive regulation of triglyceride biosynthetic process
positive regulation of heparan sulfate proteoglycan biosynthetic process
oligodendrocyte development
Wnt signaling pathway
neural tube development
pituitary gland development
bone mineralization
negative regulation of BMP signaling pathway
embryonic genitalia morphogenesis
regulation of myelination
positive regulation of insulin secretion
positive regulation of protein binding
secretory granule localization
regulation of hormone metabolic process
somatic stem cell population maintenance
multicellular organism growth
catenin import into nucleus
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast growth factor receptor signaling pathway
odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
maintenance of DNA repeat elements
skin development
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
fat cell differentiation
negative regulation of fat cell differentiation
positive regulation of gluconeogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of organ growth
positive regulation of protein export from nucleus
positive regulation of lipid biosynthetic process
embryonic digestive tract morphogenesis
embryonic hindgut morphogenesis
myoblast fate commitment
regulation of skeletal muscle tissue development
regulation of smooth muscle cell proliferation
generation of neurons
regulation of oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
face morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of canonical Wnt signaling pathway
insulin metabolic process
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
protein kinase binding
nuclear hormone receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding