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1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1
• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes
• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells
• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway
• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders
• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell
Specifications
Melting Point
218°C to 226°C
Color
White
Linear Formula
NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Quantity
5 g
Merck Index
14,5938
Solubility Information
Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Formula Weight
165.62
Physical Form
Powder
Chemical Name or Material
1,1-Dimethylbiguanide hydrochloride
Hazard Category
H302-H315-H319-H335
Hazard Statement
GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
Precautionary Statement
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber
214-230-6
RTECSNumber
DU1800000
TSCA
No
Recommended Storage
Keep cold
RUO – Research Use Only
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