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10-DEBC hydrochloride, Tocris Bioscience™

Catalog No. 255850 Shop All R&D Systems Products
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Selective Akt/PKB inhibitor

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ∽ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Chemical Identifiers

CAS

925681-41-0

Molecular Formula

C20H26Cl2N2O

Molecular Weight (g/mol)

381.341

InChI Key

SVKSJUIYYCQZEC-UHFFFAOYSA-N

Synonym

Akt Inhibitor X, 10-4′-n-diethylamino butyl-2-chlorophenoxazine, hcl, 10-4'-n,n-diethylamino butyl-2-chlorophenoxazine hydrochloride, 4-2-chlorophenoxazin-10-yl butyl diethylamine hydrochloride, 4-2-chloro-10h-phenoxazin-10-yl-n,n-diethylbutan-1-amine-hydrogen chloride 1/1

PubChem CID

16760284

IUPAC Name

4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride

SMILES

CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl

Specifications

Quantity

50 mg

Formula Weight

381.34

Percent Purity

>99%

Chemical Name or Material

10-DEBC hydrochloride

Recommended Storage

Desiccate at +4°C
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