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  7. 10-DEBC hydrochloride, Tocris Bioscience™

10-DEBC hydrochloride, Tocris Bioscience™

Catalog No. p-4783677 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective Akt/PKB inhibitor

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ∽ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Chemical Identifiers

CAS 925681-41-0
Molecular Formula C20H26Cl2N2O
Molecular Weight (g/mol) 381.341
InChI Key SVKSJUIYYCQZEC-UHFFFAOYSA-N
Synonym Akt Inhibitor X, 10-4′-n-diethylamino butyl-2-chlorophenoxazine, hcl, 10-4'-n,n-diethylamino butyl-2-chlorophenoxazine hydrochloride, 4-2-chlorophenoxazin-10-yl butyl diethylamine hydrochloride, 4-2-chloro-10h-phenoxazin-10-yl-n,n-diethylbutan-1-amine-hydrogen chloride 1/1
PubChem CID 16760284
IUPAC Name 4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride
SMILES CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 381.34
Percent Purity >99%
Chemical Name or Material 10-DEBC hydrochloride

Safety and Handling

Recommended Storage Desiccate at +4°C
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