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2-(2-Bromoethyl)-1,3-dioxane, 98%, Thermo Scientific Chemicals
2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked β-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.
Solubility
It is not soluble in water but soluble in organic solvent such as ethanol.
Notes
Air, Heat sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
Specifications
Density
1.434
Boiling Point
67°C to 70°C (3 mmHg)
Flash Point
96°C (204°F)
Refractive Index
1.482
Quantity
50 g
Beilstein
1421628
Solubility Information
It is not soluble in water but soluble in organic solvent such as ethanol.
IUPAC Name
2-(1-bromoethyl)-1,3-dioxane
Formula Weight
195.06
Percent Purity
98%
Hazard Category
H315-H319-H341
Hazard Statement
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement
P201-P202-P264b-P280i-P281-P302+P352-P305+P351+P338-P308+P313-P332+P313-P362-P501c
EINECSNumber
251-716-7
TSCA
Yes
Recommended Storage
Keep cold; Store under Nitrogen
RUO – Research Use Only
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