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2-APB, Tocris Bioscience™

Catalog No. 122450 Shop All R&D Systems Products
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IP3 receptor antagonist. Also TRP channel modulator

A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

Chemical Identifiers

CAS

524-95-8

Molecular Formula

C14H16BNO

Molecular Weight (g/mol)

225.10

MDL Number

MFCD00014823

InChI Key

BLZVCIGGICSWIG-UHFFFAOYSA-N

Synonym

2-aminoethyl diphenylborinate, 2-apb, 2-aminoethoxy diphenylborane, 2-aminoethoxydiphenylborane, 2-aminoethoxydiphenylborate, 2-aminoethoxydiphenyl borate, o-2-aminoethyl diphenylborinic acid, b-2-aminoethoxy diphenylborane, 2-diphenylboryl oxy ethanamine, borinic acid, o-2-aminoethyl diphenyl

PubChem CID

1598

IUPAC Name

2-aminoethyl diphenylborinate

SMILES

NCCOB(C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Quantity

50 mg

Formula Weight

225.1

Percent Purity

>98%

Chemical Name or Material

2-APB

Recommended Storage

Store at Room Temperature
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