2-APB, Tocris Bioscience™

Description

IP3 receptor antagonist. Also TRP channel modulator

A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

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Specifications

Chemical Identifiers

• CAS: 524-95-8
• Molecular Formula: C14H16BNO
• Molecular Weight (g/mol): 225.10
• MDL Number: MFCD00014823
• InChI Key: BLZVCIGGICSWIG-UHFFFAOYSA-N
• Synonym: 2-aminoethyl diphenylborinate, 2-apb, 2-aminoethoxy diphenylborane, 2-aminoethoxydiphenylborane, 2-aminoethoxydiphenylborate, 2-aminoethoxydiphenyl borate, o-2-aminoethyl diphenylborinic acid, b-2-aminoethoxy diphenylborane, 2-diphenylboryl oxy ethanamine, borinic acid, o-2-aminoethyl diphenyl
• PubChem CID: 1598
• IUPAC Name: 2-aminoethyl diphenylborinate
• SMILES: NCCOB(C1=CC=CC=C1)C1=CC=CC=C1

• Quantity: 10 mg
• Formula Weight: 225.1
• Percent Purity: >98%
• Chemical Name or Material: 2-APB

Safety and Handling

Recommended Storage

Store at Room Temperature