Thermo Scientific Chemicals 2'-Deoxyuridine, 98+%, Thermo Scientific Chemicals

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2?-Deoxyuridines used as labeling substrates include chloro-2?-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2?-deoxyuridine include 5-ethynyl-2?-deoxyuridine (DdU) and 5-hydroxymethyl-2?-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2′-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-Deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Solubility
Soluble in water.

Notes
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to air.

Chemical Identifiers

CAS

951-78-0

Molecular Formula

C9H12N2O5

Molecular Weight (g/mol)

228.20

MDL Number

MFCD00006527

InChI Key

MXHRCPNRJAMMIM-SHYZEUOFSA-N

Synonym

2'-deoxyuridine, deoxyuridine, uracil deoxyriboside, 2-deoxyuridine, 1-2r,4s,5r-4-hydroxy-5-hydroxymethyl tetrahydrofuran-2-yl pyrimidine-2,4 1h,3h-dione, deoxyribose uracil, uridine, 2'-deoxy, 2'-desoxyuridine, unii-w78i7ay22c, ccris 2832

PubChem CID

13712

ChEBI

CHEBI:16450

IUPAC Name

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

SMILES

OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O

Melting Point

164°C to 167°C

Quantity

25 g

Beilstein

24433

Sensitivity

Air Sensitive

Merck Index

14,2910

Solubility Information

Soluble in water.

Optical Rotation

+52° (c=1.1 in 1N NaOH)

Formula Weight

228.21

Percent Purity

99%

Chemical Name or Material

2'-Deoxyuridine

EINECSNumber

213-455-7

RTECSNumber

YU7490000

TSCA

Yes

Recommended Storage

Ambient temperatures

SDS

EINECSNumber

213-455-7

RTECSNumber

YU7490000

TSCA

Yes

Recommended Storage

Ambient temperatures

SDS

RUO – Research Use Only