3-Deazaneplanocin A hydrochloride, Tocris Bioscience™

EZH2 histone methyltransferase inhibitor

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

DZNep synthesized to Ancillary Material Grade also available.

For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Chemical Identifiers

CAS

120964-45-6

Molecular Formula

C12H15ClN4O3

Molecular Weight (g/mol)

298.727

InChI Key

UNSKMHKAFPRFTI-FDKLLANESA-N

Synonym

3-deazaneplanocin a hydrochloride, 3-deazaneplanocin a dznep hcl, 3-deazaneplanocin, hcl salt, 3-deazaneplanocin a dznep hydrochloride, c12h14n4o3.clh, 3-deazaneplanocin a hydrochloride hplc, --1-1r,4r,5s-3-hydroxymethyl-4,5-dihydroxy-2-cyclopenten-1-yl 4-aminoimidazo 4,5-c pyridinehydrochloridedznephydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl-3-cyclopentene-1,2-diol hydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl cyclopent-3-ene-1,2-diol-hydrogen chloride 1/1

PubChem CID

14563109

IUPAC Name

(1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;hydrochloride

SMILES

C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl

Quantity

1 mg

Formula Weight

298.73

Percent Purity

>98%

Chemical Name or Material

3-Deazaneplanocin A hydrochloride

Recommended Storage

Store at -20°C

Recommended Storage

Store at -20°C