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(-)-[3R,4S]-Chromanol 293B, Tocris Bioscience™

Catalog No. 147550 Shop All R&D Systems Products
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IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM).

Racemate also available.

Chemical Identifiers

CAS

163163-24-4

Molecular Formula

C15H20N2O4S

Molecular Weight (g/mol)

324.395

InChI Key

HVSJHHXUORMCGK-UONOGXRCSA-N

Synonym

chromanol 293b, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-4-yl-n-methylethanesulfonamide, ethanesulfonic acid 6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl-methyl-amide, 6-cyano-4-n-ethylsulfonyl-n-methylamino-3-hydroxy-2,2-dimethyl chromane, n-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl-n-methylethanesulfonamide

PubChem CID

121846

ChEBI

CHEBI:34637

IUPAC Name

N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide

SMILES

CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O

Specifications

Quantity

50 mg

Formula Weight

324.39

Percent Purity

>99%

Chemical Name or Material

(-)-[3R, 4S]-Chromanol 293B

Recommended Storage

Store at Room Temperature
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