5,6-Dichlorobenzimidazole riboside, 98%, Thermo Scientific Chemicals

Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

Solubility
Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

Notes
Incompatible with heat and oxidizing agents.

Chemical Identifiers

CAS

53-85-0

Molecular Formula

C12H12Cl2N2O4

Molecular Weight (g/mol)

319.138

MDL Number

MFCD00036785

InChI Key

XHSQDZXAVJRBMX-DDHJBXDOSA-N

Synonym

5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole, dichlororibofuranosylbenzimidazole, drb, 5,6-dichlorobenzimidazole riboside, 5,6-dichlorobenzimidazole 1-beta-d-ribofuranoside, 5,6-dichloro-1-.beta.-d-ribofuranosylbenzimidazole, benzimidazole, 5,6-dichloro-1-beta-d-ribofuranosyl, 5,6-dichloro-1-beta-d-ribofuranosyl-1h-benzimidazole, 2r,3r,4s,5r-2-5,6-dichloro-1,3-benzodiazol-1-yl-5-hydroxymethyl oxolane-3,4-diol, 2r,3r,4s,5r-2-5,6-dichloro-1h-1,3-benzodiazol-1-yl-5-hydroxymethyl oxolane-3,4-diol

PubChem CID

5894

IUPAC Name

(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol

SMILES

C1=C2C(=CC(=C1Cl)Cl)N(C=N2)C3C(C(C(O3)CO)O)O

Color

White

Quantity

50 mg

Beilstein

39123

Solubility Information

Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide,hot ethanol,dimethyl formamide,(1:2) dimethyl formamide:Phosphate buffer saline,water,methanol and pyridine; Slightly soluble in aqueous buffers.

Formula Weight

319.14

Percent Purity

98%

Physical Form

Powder

Chemical Name or Material

5,6-Dichlorobenzimidazole riboside

RTECSNumber

DD7310000

TSCA

No

Recommended Storage

Store at -20°C

SDS

RTECSNumber

DD7310000

TSCA

No

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only