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5,7-Dihydroxy-4'-methoxyisoflavone, 98%, Thermo Scientific Chemicals
It has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. It acts as an antineoplastic agent. It is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects. It is a nitric oxide synthase inhibitor and apoptosis inducer
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Specifications
Melting Point
210°C to 213°C
Quantity
250 mg
Beilstein
278107
Solubility Information
Soluble in water (<1mg/ml at 25°C),chloroform,methanol,DMSO (57mg/ml at 25°C),and ethanol (9mg/ml at 25°C).
Formula Weight
284.27
Percent Purity
98%
Physical Form
Powder
Chemical Name or Material
5,7-Dihydroxy-4'-methoxyisoflavone
EINECSNumber
207-744-7
TSCA
Yes
Recommended Storage
Ambient temperatures
RUO – Research Use Only
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