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5-Bromo-2'-deoxyuridine, 99%, Thermo Scientific Chemicals

Catalog No. AAH27260MD
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5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
5-Bromo-2′-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Solubility
Soluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Chemical Identifiers

CAS

59-14-3

Molecular Formula

C9H11BrN2O5

Molecular Weight (g/mol)

307.10

MDL Number

MFCD00006529

InChI Key

WOVKYSAHUYNSMH-RRKCRQDMSA-N

Synonym

5-bromo-2'-deoxyuridine, broxuridine, bromodeoxyuridine, brdu, 5-bromodeoxyuridine, 5-brdu, budr, 5-bromouracil deoxyriboside, bromouracil deoxyriboside, 5-bromodesoxyuridine

PubChem CID

6035

ChEBI

CHEBI:472552

IUPAC Name

5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

SMILES

OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(Br)C(=O)NC1=O

Specifications

Melting Point

∽190°C (decomposition)

Quantity

250 mg

Beilstein

30395

Merck Index

14,1452

Solubility Information

Soluble in water.

Optical Rotation

+31° (c=1 in 0.1N HCl)

Formula Weight

307.1

Percent Purity

99%

Chemical Name or Material

5-Bromo-2'-deoxyuridine

Hazard Category

H315-H319-H335-H341

Hazard Statement

GHS H Statement
H341
Suspected of causing genetic defects.

Precautionary Statement

P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c

EINECSNumber

200-415-9

RTECSNumber

YU7350000

TSCA

Yes

Recommended Storage

Keep cold
SDS

RUO – Research Use Only

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