AG 1478 hydrochloride, Tocris Bioscience™

Description

Highly potent EGFR-kinase inhibitor

Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 μM).

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Specifications

Chemical Identifiers

• CAS: 170449-18-0
• Molecular Formula: C16H15Cl2N3O2
• Molecular Weight (g/mol): 352.215
• InChI Key: WDJDYIUSDDVWKB-UHFFFAOYSA-N
• Synonym: n-3-chlorophenyl-6,7-dimethoxyquinazolin-4-amine hydrochloride, tyrphostin hydrochloride, 6,7-dimethoxy-4-n-3-chlorophenyl amino quinazoline hydrochloride, ag 1478 hydrochloride, n-3-chlorophenyl-6,7-dimethoxy-4-quinazolinamine monohydrochloride, 4-3-chloroanilino-6,7-dimethoxyquinazoline hcl, 4-quinazolinamine, n-3-chlorophenyl-6,7-dimethoxy-, monohydrochloride, rtki cpd, ag1478 hydrochloride, ag-1478 hydrochloride/
• PubChem CID: 3035187
• IUPAC Name: N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl

• Quantity: 10 mg
• Formula Weight: 352.22
• Percent Purity: >98%
• Chemical Name or Material: AG 1478 hydrochloride

Safety and Handling

Recommended Storage

Desiccate at -20°C