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AMG 548, Tocris Bioscience™

Catalog No. 392010 Shop All R&D Systems Products
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective p38α inhibitor

Potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.

Chemical Identifiers

CAS 864249-60-5
Molecular Formula C29H27N5O
Molecular Weight (g/mol) 461.569
InChI Key RQVKVJIRFKVPBF-VWLOTQADSA-N
Synonym unii-pgr0h531i4, d02mvg, p38 map kinase inhibitor, amgen, s-2-2-amino-3-phenylpropylamino-3-methyl-5-naphthalen-2-yl-6-pyridin-4-yl pyrimidin-4 3h-one, 2-2s-2-amino-3-phenylpropyl amino-3-methyl-5-2-naphthalenyl-6-4-pyridinyl-4 3h-pyrimidinone, 4 3h-pyrimidinone, 2-2s-2-amino-3-phenylpropyl amino-3-methyl-5-2-naphthalenyl-6-4-pyridinyl
PubChem CID 11167112
IUPAC Name 2-[[(2S)-2-amino-3-phenylpropyl]amino]-3-methyl-5-naphthalen-2-yl-6-pyridin-4-ylpyrimidin-4-one
SMILES CN1C(=O)C(=C(N=C1NCC(CC2=CC=CC=C2)N)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4

Specifications

Quantity 10 mg
Formula Weight 461.56
Percent Purity >98%
Chemical Name or Material AMG 548

Safety and Handling

Recommended Storage Store at -20°C
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